薛国菊,时涛,钱文璟,杨燕妮
XUE Guo-ju~1, SHI Tao~1,QIAN Wen-jing~1,YANG Yan-ni~2 (1.Dept.of Pharmacy

• 1:深圳市第二人民医院药剂科
• 2:深圳市第二人民医院药剂科
• 3:深圳市第二人民医院药剂科
• 4:苏州大学药学院 广东深圳518035

摘要(Abstract)：

目的考察注射用丹参(冻干)与临床常用输液配伍后的稳定性情况。方法模拟临床用药方法,将注射用丹参与0·9%氯化钠注射液、5%葡萄糖注射液配伍,测定配伍后溶液6h内pH值、不溶性微粒数和丹参素与原儿茶醛的含量。结果注射用丹参与0.9%氯化钠注射液、5%葡萄糖注射液配伍后溶液6h内pH值变化较小;配伍液不溶性微粒数远远高于原注射液的不溶性微粒数(P<0.01);主要成分丹参素钠和原儿茶醛的含量基本无变化。结论注射用丹参与输液配伍后6h内质量基本稳定。但配伍后溶液不溶性微粒数比原输液大大增多的现象必须引起重视。
Objective To study the stability of Danshen injection (Lyophilized Powder) in 0.9% sodium chloride injection and 5% glucose injection. Methods Simulating the clinical usage, the pH, insoluable particles and contents of danshensu、protocatechuic aldehyde were determined in compatible solution within 6 hours. Results There were almost no changes in pH and the contents of danshensu、protocatechuic aldehyde in compatible solution within 6 hours. The number of insoluable particles in compatible solution were much higher than those of 0.9% sodium chloride injection and 5% glucose injection. Conclusion The quality of Danshen injection in compatible solution is stabile within 6 hours. But much attention should be paid to the numbers of insoluable particles.

关键词(KeyWords)： 注射用丹参;输液;配伍;稳定性
Danshen injection; transfusion; compatible; stability

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 薛国菊,时涛,钱文璟,杨燕妮
XUE Guo-ju~1, SHI Tao~1,QIAN Wen-jing~1,YANG Yan-ni~2 (1.Dept.of Pharmacy

参考文献(References)：

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