今日药学

2018, v.28(06) 369-373

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利培酮微球注射剂与口服剂改善精神分裂症小鼠认知能力的比较
A Comparative Study of Risperidone Microspheres Injection and Oral Administration in Improving Cognitive Functions of Schizophrenia Mice

黄小舟;刘珠英;沈剑兰;
HUANG Xiaozhou;LIU Zhuying;SHEN Jianlan;Department of Pharmacy,The South China Normal University Hospital;Department of Pharmacy,The Third Affiliated Hospital of Sun Yat-sen University;

摘要(Abstract):

目的比较注射用长效利培酮微球与常用口服剂型治疗精神分裂症的临床疗效与安全性。方法选取10只野生型对照小鼠,30只精神分裂症转基因小鼠(TMc-Nrg1+/-)随机分为3组,每组10只。第一组小鼠注射利培酮微球3.75 mg·kg~(-1),两周1次;第二组小鼠每日0.6 mg·kg~(-1)利培酮经口灌胃,第三组为阴性对照组,对照小鼠每日2 m L 0.9%Na Cl溶液经口灌胃。采用行为学检测手段评定疗效;分别在治疗后的第4周、第8周评定疗效与不良反应。结果长效利培酮微球治疗后第4周、第8周的社交能力、学习记忆能力与阴性对照组比较,差异有统计学意义(P<0.05),与正常野生型小鼠比较差异无统计学意义。长效利培酮微球治疗后第4周、第8周行为改变(社交能力及学习记忆能力)与口服剂型比较,差异有统计学意义(P<0.05)。结论与常用口服剂型比较,注射用长效利培酮微球治疗精神分裂症具有明显的临床疗效与安全性。
OBJECTIVE To investigate the clinical efficacy and safety of long-acting injectable risperidone( RLAI) and oral administration in the treatment of schizophrenia. METHODS Ten wild-type control mice were used as control group,30 schizophrenic transgenic mice( TMc-Nrg1 +/-) were randomly divided into 3 groups with 10 cases in each group. Group 1 mice were injected with risperidone microspheres for the first time at 3.75 mg·kg~(-1),once every two weeks. Group 2 mice were orally administrated with risperone oral solution( ROS) for 0.6 mg·kg~(-1),everyday.The control group mice were orally administrated with 2 m L 0.9% Na Cl,once a day. The effectiveness of two treatments were evaluated by behavioral test. The efficacy and side effects were evaluated at the 4 th week and 8 th weeks after initial treatment. RESULTS As compared to saline-treated schizophrenia mice,the social ability,learning and memory were significantly better in risperidone microspheres administration group at 4 weeks and 8 weeks after treatment( P<0.05). There were significant differences in behavioral changes( social ability,learning and memory ability) between risperidone microspheres injection and oral administration( P< 0. 05). CONCLUSION The treatment of schizophrenia with long-acting risperidone microspheres has obvious clinical efficacy and safety.

关键词(KeyWords): 利培酮;微球;精神分裂症;认知能力;小鼠
risperidone;microspheres;schizophrenia;cognitive ability;mice

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作者(Author): 黄小舟;刘珠英;沈剑兰;
HUANG Xiaozhou;LIU Zhuying;SHEN Jianlan;Department of Pharmacy,The South China Normal University Hospital;Department of Pharmacy,The Third Affiliated Hospital of Sun Yat-sen University;

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