今日药学

2015, v.25(06) 450-452

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不同药物治疗慢性乙型肝炎患者血清miRNA的变化及意义
Change of miRNA Expression in Serum of Chronic Hepatitis B Patients Treated with Different Antiviral Treatment Options

唐波;李伟;叶丽卡;王若伦;冯霞;
TANG Bo;LI Wei;YE Lika;WANG Ruolun;FENG Xia;Department of Pharmacy,The Second Affiliated Hospital of Guangzhou Medical University;The Department of Gastroenterology,Guangdong Provincial Corps Hospital,Chinese People's Armed Police Forces;

摘要(Abstract):

目的观察阿德福韦酯、注射用重组人干扰素α2b治疗慢性乙型肝炎患者血清中miRNA的变化及临床意义。方法选取2012-05~2013-05省武警医院消化内科门诊的100例慢性乙型肝炎患者为研究对象,根据治疗用药不同,分为阿德福韦酯组和干扰素组各50例,分别口服阿德福韦酯胶囊5 mg/d和皮下注射干扰素针100万单位/周,应用芯片杂交技术分析患者在治疗期间血清中miR-122、miR-19b的变化。结果 miR-122、miR-19b在阿德福韦酯组治疗后的表达量分别为(75.26±13.43)(88.64±15.36)fmol/L,在干扰素组治疗后的表达量分别为(65.18±22.08)(69.32±25.17)fmol/L,各组治疗后各指标均高于治疗前,差异均有统计学意义(P<0.05),但2组间治疗前后差异无统计学意义(P>0.05)。结论阿德福韦酯与注射用重组人干扰素α2 b均可上调慢性乙型肝炎患者血清miR-122、miR-19b的表达,可能为其发挥作用的机制之一。
OBJECTIVE To study the change and clinical significance of expression of miRNA in the serum of chronic hepatitis B patients treated with adefovir dipivoxil( ADV) and interferon( IFN). METHODS A total of 100 cases of patients with chronic hepatitis B were selected as the research objects,and were divided into the ADV(5 mg / d) treatment group and the IFN( one million units per week) treatment group with 50 cases in each according to the different drug treatment. The expressions of miR-122 and miR-19 b in the serum of all the patients during the treatment were determined by microarray technology. RESULTS After the treatment,the contents of expression of miR-122,miR-19 b in the ADV treatment group were( 75. 26 ± 13. 43) and( 88. 64 ± 15. 36) fmol / L,which were(65. 18 ± 22. 08) and(69. 32 ± 25. 17) fmol / L in the IFN treatment group,all the indexes were higher after the treatment than before the treatment( P < 0. 05),there was no significant difference between 2 groups( P > 0. 05). CONCLUSION The increased contents of miR-122 and miR-19 b in the serum of the 2 groups were probably patent mechanism.

关键词(KeyWords): 慢性乙型肝炎;miRNA;miR-122;miR-19b
chronic hepatitis B;miRNA;miR-122;miR-19b

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作者(Author): 唐波;李伟;叶丽卡;王若伦;冯霞;
TANG Bo;LI Wei;YE Lika;WANG Ruolun;FENG Xia;Department of Pharmacy,The Second Affiliated Hospital of Guangzhou Medical University;The Department of Gastroenterology,Guangdong Provincial Corps Hospital,Chinese People's Armed Police Forces;

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