乙肝基因治疗研究
蒋英丽,周向军
摘要(Abstract)：
本文对乙肝的现状、乙肝基因治疗的临床前研究及临床研究进行了综述。肯定了乙肝基因疫苗在治疗HBV感染方面具有很大的潜力和优势。
关键词(KeyWords)：
乙肝;基因疫苗;CTL反应
基金项目(Foundation):
作者(Author):
蒋英丽,周向军
参考文献(References)：
- [1]Lee WM.Hepatitis B virus infection[J].New Engl JM ed,1997,337:1733-45.
- [2]Hoofnagle JH,Lau D.New therap ies for chron ic hepatitis B[J].V iralHepat,1997,4:41-50.
- [3]Hoofnagle JH,d i B isceglie AM.The treatm ent of chron ic vi-ral hepatitis[J].New Engl JM ed 1997,336:347-56.
- [4]L iaw,Y.-F.,D.-I.Tai,et al.The developm ent of c irrhosisin patients w ith chron ic type B hepatitis:a prospective study[J].Hepatology,1988,8:493-496.
- [5]Lok,A.S.F.,and C.-L.Lai.A longitud inal follow-up ofasymptom aic hepatitis B surface antigen-positive ch ildren[J].Hepatology,1988,(8):1130-1133.
- [6]M cM ahon,B.J.,S.R.A lbrets,et al.Hepatitis B-related se-quence:prospective study in 1400 hepatitis B surface anti-gen-positive A laska native carriers[J].Arch.Intern.M ed,1990,150:1051-1054.
- [7]Lok ASF,W u PH.A controlled trial of interferon w ith orw ithout predn isone prim ing for chron ic hepatitis B[J].Gas-terology,1992,102:2091-2097.
- [8]焦文举,张甫.六种疗法对乙型慢性活动性肝炎的疗效比较[J].中华传染病杂志,1994,12(2):114-115.
- [9]李聪智,谢玉挑,刘双湖.α-干扰素治疗慢性乙型肝炎疗效追踪4年[J].中国现代医学杂志,1999,9(4):1-3.
- [10]M asonW S,Cu llen J,Moraleda J,et al[J].V irology,1998,245(1):18-32.
- [11]Rob inson HL,Torres CA,DNA vacc ine[J].W em inars inImmunology,1997,9:271-283.
- [12]LohrH,W eberW,Schlaak,et al.Proliferative responseof CD4+T cells and hepatitis B virus c learance In chron-ic hepatitis B w ith orw ithout hepatitis B e-m inus hepatitisB virus mutants.(J)Hepatology,1995,22:65-8.
- [13]Reherm ann B,Fow ler P,S idney J.Thecytotoxic T lym-phocyte response to mu ltip le hepatitis B virus polym eraseep itopes during and after acute viral hepatitis[J].Exp.M ed,1995,181:1047-1058.
- [14]Penna A.,Ch isari F.V.,Bertoletti A.Cytotoxic T lym-phocytes recogn ize an HLA-A2 restricted ep itope w ith inthe hepatitis B virus nuc leocapsid antigen[J].Exp.M ed,1991,174:1565-1570.
- [15]M ain iM.K.,Bertoletti A..How can the cellu lar immuneresponse control hepatitis B virus rep lication[J].V iralHepat,2000,7:321-326.
- [16]M anc in iM,HadchouelM,Tiollais P,et al.Regu la-tionof hepatitis B virus mRNA expression in a hepatitis B sur-face antigen transgen ic mouse model by IFN-_-secreting Tcells after DNA-based immu-n ization[J].Immunol,1998,161:5564-5570.
- [17]M anc in i M,Hadchouel M,Davis HL.DNA-m ed iated im-mun ization in a transgen ic mouse model of the hepatitis Bsurface antigen chron ic carrier state[J].Proc Nar I AcadSc i USA,1996,93:12496-12501.
- [18]Luca G.Gu idotti et al.Cytotoxic T lymphocytes inh ib ithepatitis B virus gene expression by a noncytolytic m echa-n ism in transgen ic m ice[J].Immunology,1994,91:3764-3768.
- [19]Ge isslerM,Tokush ige K,Chante CC,et al.Cellu lar and hu-moral immune response to hepatitis B virus structural pro-te ins in m ice after DNA-based immun ization[J].Gastroen-terology,1997,112:1307-1320.
- [20]Kuhober A,Pudollek HB,Re ifenberg K,et al.DNA im-mun ization induces antibody and cytotoxic T cell responsesto hepatitis B core antigen in H-2b m ice[J].Immunol,1996,156:3687-3695.
- [21]JensW ild,Cruner B,M etEgerK,et al.Polyvalent vacc ina-tion against hepatitis B surface and core antigen using ad ic istron ic expression p lasm id[J].Vacc ine,1998,16(4):353-360.
- [22]KAY Townsend.Characterization of CD8+Cytotoxic T-lym-phocyte responses after genetic immunization with retrovirusvectors expressing d ifferent forms of the hepatitis B virus coreand e antigens[J].virology,1997:3365-3374.
- [23]zu hu huang,Zhang H,Lu S,et al.Humoral and cellu larimmunogenec ity of DNA vacc ine based on hepatitis B coregene in rhesus monkeys[J].W orld Gastroenterol,2001,(1):102-106.
- [24]SallbergM,Hughes J,Javad ian A,et al.Genetic immu-n ization of ch impanzees chron ically infected w ith the hepa-titis B virus,using a recomb inant retroviral vector enco-d ing the hepatitis B virus core antigen[J].Hum Gen T-her,1998,9:1719-1729.
- [25]A lfred M.Prince.Successfu l nuc le ic ac id based immun iza-tion of newborn ch impanzees against hepatitis B virus[J].Vzcc ine,1997,15(8):916-919.
- [26]Tacket CO Rou M J,W idera G.Phage 1 safety and immuneresponse stud ies of a DNA vacc ine encod ing hepatitis Bvirus surface antigen delivered by a gene delivery device[J].Vacc ine,1999,17:2826-2829.
- [27]M ichae l J.R oy.Induction of antigen-spec ific CD8+Tce lls,T he lper ce lls,and protentive leve ls of antibody inhum ans by partic le-m ed iated adm in istration of a hepati-tis B virus DNA vacc ine[J].Vacc ine,2001,19:764-778.
- [28]M aryline M anc in i-Bourgine.Induction or expansion of T-cell responses by a hepatitis B DNA vacc ine adm in isteredto chron ic HBV carriers[J].Hepatology,2004,40(4).