王丽平,陆小路,赵宗杰
WANG Liping,LU Xiaolu,ZHAO Zongjie

• 1:广东省食品药品监督管理局
• 2:广州市培正中学
• 3:深圳市仁泰生物科技有限公司

摘要(Abstract)：

本文介绍了牛樟芝的使用历史、中药归经及功效,汇总了在中国大陆地区牛樟芝的临床前研究和栽培技术发展的现状以及研究进展。
This paper introduces the history,channel tropism and function of Antrodia camphorata,summarizes the preclinical research,cultivation technology and development in mainland China.

关键词(KeyWords)： 牛樟芝;历史;中药特性;临床前研究;栽培
Antrodia camphorata;history;Properties and function of Chinese Herbal Medicine;preclinical research;cultivation

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 王丽平,陆小路,赵宗杰
WANG Liping,LU Xiaolu,ZHAO Zongjie

参考文献(References)：

• [1]Geethangili M T,Zeng Y M.Reviewof pharmacological effects of Antrodia camphorata and its bioactive compounds[J].Evidence-Based Complemen-tary and Alternative Medicine,2009,2011(2011):1-15.
• [2]臧穆,苏庆华.我国台湾产灵芝属一新种---樟芝[J].云南植物研究,1990,12(4):395-396.
• [3]T T.Chang,W N.Chou.Antrodia cinnamomea sp.Nov.on Cinnamomum kanehirai in Taiwan[J].Mycological Research,1995,99(6):756-758.
• [4]SH WU,Z H YU,C T Dai,et al.Taiwanfungus,apolypore new genus[J].Fung Sci,2004,19(3-4):109-116.
• [5]Sheng-Hua Wu,Leif Ryvarden,Tun-Tschu Chang.Antrodia Camphorata(“niu-chang-chih”),new combination of a medicinal fungus in Taiwan[J].Bot Bull Acad Sin,1997,38:273-275.
• [6]苏庆华.健康的守护神国宝樟芝[M].台北市:爱克思文化事业有限公司,2002:28-33.
• [7]苏志诚.台湾牛樟芝的性味、归经与功效的探讨[J]中医临床研究,2013,5(20):26-30.
• [8]李顺来.台湾国宝牛樟芝[M].新北市:世茂出版有限公司,2009:15-18.
• [9]Huang C C,Cheng H H,Wang J L,et al.Effects of Antrodia camphorata Extracts on the Viability,Apoptosis,[Ca2+],and MAPKs Phosphorylation of OC2 Human Oral Cancer Cells[J].Chinese Journal of Physiology,2009,52(3):128-135.
• [10]Tsai M C,Song T Y,Shih P H,et al.Antioxidant properties of water-soluble polysaccharides from Antrodia cinnamomea in submerged culture[J].Food Chemistry,2007,104:1115-1122.
• [11]Lin Y W,Pan J H,Liu R H,et al.The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells[J].Jsci Food Agric,2010,90(10):1739-1744.
• [12]Du Y C,Chang F R,Wu TY,et al.Antileukemia component,dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models[J].Phytomedicine,2012,19,788-796.
• [13]Hseu Y C,Yang H L,Lai Y C,et al.Induction of Apoptosis by Antrodia camphorata in Human Premyelocytic Leukemia HL-60 Cells[J].Nutrition and Cancer,2004,48(2):189-197.
• [14]Lu M K,Cheng J J,Lai W L,et al.Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A2A receptors[J].Life Sciences,2006,79(3):252-258.
• [15]Lu M C,Du Y C,Chuu J J,et al.Active extracts of wild fruiting bodies of Antrodia camphorata(EEAC)induce leukemia HL 60cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A[J].Arch Toxicol,2009,83(2):121-129.
• [16]Chen Y J,Chou C J,Chang T T.Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells[J].Toxicology in Vitro,2009,23:418-424.
• [17]Yu C C,Chiang P C,Lu P H,et al.Antroquinonol,a natural ubiquinone derivative,induces a cross talk between apoptosis,autophagy and senescence in human pancreatic carcinoma cells[J].Journal of Nutritional Biochemistry,2012,23(8):900-907.
• [18]Chen Y Y,Chou P Y,Chien Y C,et al.Ethanol extracts of fruiting bodies of Antrodia cinnamomea exhibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K/AKT signaling pathways[J].Phytomedicine,2012,19(8-9):768-778.
• [19]Lin Y W,Pan J H,Liu R H,et al.The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells[J].Jsci Food Agric,2010,90(10):1739-1744.
• [20]Hsieh Y C,Rao Y K,Whang-Peng J,et al.Antcin B and Its Ester Derivative from Antrodia camphorata Induce Apoptosis in Hepatocellular Carcinoma Cells Involves Enhancing Oxidative Stress Coincident with Activation of Intrinsic and Extrinsic Apoptotic Pathway[J].J Agric Food Chem,2011,59(20):10943-10954.
• [21]Hseu Y C,Chen S C,Yech Y J,et al.Antioxidant activity of Antrodia Camphorata on free radical-induced endothelial cell damage[J].Journal of Ethnopharmacology,2008,118:237-245.
• [22]Lee Y P,Tsai W C,KO C J,et al.Anticancer Effects of Eleven Triterpenoids Derived from Antrodia camphorata[J].Anticancer Research,2012,32(7):2727-2734.
• [23]Yang H L,Hseu Y C,Chen J Y,et al.Antrodia Camphorata in Submerged Culture Protects Low Density Lipoproteins Against Oxidative Modification[J].The American Journal of Chinese Medicine,2006,34(2):217-231.
• [24]Hseu Y C,Yang H L,Lai Y C,et al.Induction of Apoptosis by Antrodia camphorata in Human Premyelocytic Leukemia HL-60 Cells[J].Nutrition and Cancer,2004,48(2):189-197.
• [25]Liu F S,Yang P Y,Hu D N,et al.Antrodia camphorata Induces Apoptosis and Enhances the Cytotoxic Effect of Paclitaxel in Human Ovarian Cancer Cells[J].International Journal of Gynecological Cancer,2011,21(7):1172-1179.
• [26]Yang H L,Lin K Y,Juan Y C,et al.The anti-cancer activity of Antrodia camphorata against human ovarian carcinoma(SKOV-3)cells via modulation of HER-2/neu signaling pathway[J].Journal of Ethnopharmacology,2013,148(1):254-265.
• [27]Peng C C,Chen K C,Peng R Y,et al.Human urinary bladder cancer T24 cells are susceptible to the Antrodia camphorata extracts[J].Cancer Letters,2006,243(1):109-119.
• [28]Peng C C,Chen K C,Peng R Y,et al.Antrodia camphorata extract induces replicative senescence in superficial TCC,and inhibits the absolute migration capability in invasive bladder carcinoma cells[J].Journal of Ethnopharmacology,2007,109:93-103.
• [29]Wei P L,Tu S H,Lien H M,et al.The in vivo antitumor effects on human COLO 205 cancer cell of the 4,7-Dimethoxy-5-Methyl-l,3-Benzodioxole(SY-1)isolated from the fruiting body of Antrodia camphorata[J].Journal of Cancer Research and Therapeutics,2012,8(4):532-536.
• [30]Lien H M,Kuo P T,Huang C L,et al.Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO205Colon Cancer Cells[J].Evidence-Based Complementary and Alternative Medicine,2011,2011:1-8.
• [31]Yeh C T,Rao Y K,Yao C J,et al.Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells[J].Cancer Letters,2009,285(1):73-79.
• [32]Chen Y C,Liu Y L,Li F Y,et al.Antcin A,a steroid-like compound from Antrodia camphorata,exerts anti-inflammatory effect via mimicking glucocorticoids[J].Acta Pharmacol Sin,2011,32:904-911.
• [33]Ho Y C,Lin M T,Duan K J,et al.The hepatoprotective activity against ethanol-induced cytotoxicity by aqueous extract of Antrodia cinnamomea[J].Journal of the Chinese Institute of Chemical Engineers,2008,39:441-447.
• [34]Liu F S,Yang P Y,Hu D N,et al.Antrodia camphorate Induces Apoptosis and Enhances the Cytotoxic Effect of Paclitaxel in Human Ovarian Cancer Cells[J].International Journal of Gynecological Cancer,2011,21(7):1172-1179.
• [35]Jhu-Yun Deng,Sian-Jin Chen,Guey-Mei Jow,et al.Dehydroeburicoic Acid Induces Calcium-and Calpain-Dependent Necrosis in Human U87MG Glioblastomas[J].Chem Res Toxicol,2009,22,1817-1826.
• [36]Yang C M,Zhou Y J,Wang R J,et al.Anti-angiogenic effects and mechanisms of polysaccharides from Antrodia cinnamomea with different molecular weights[J].Journal of Ethnopharmacology,2009,123:407-412.
• [37]Lin C J,Rao Y K,Hung C L,et al.Inhibition of Helicobacter pylori Cag A-Induced Pathogenesis by Methylantcinate B from Antrodia Camphorata[J].Evidence-Based Complementary and Alternative Medicine,2013:1-12.
• [38]Song T Y,Yen G C.Protective Effects of Fermented Filtrate from Antrodia camphorata in Submerged Culture against CCl4-Induced Hepatic Toxicity in Rats[J].Journal of Agricultural and Food Chemistry,2003,51:1571-1577.
• [39]Han H F,Nakamura N,Zuo F,et al.Protective Effects of a Neutral Polysaccharide Isolated from the Mycelium of Antrodia cinnamomea on Propionibacteriumacnes and Lipopolysaccharide Induced Hepatic Injury in Mice[J].Chem Pharm Bull,2006,54(4):496-500.
• [40]Hsieh Y C,Rao Y K,Whang-Peng J,et al.Antcin B and Its Ester Derivative from Antrodia camphorata Induce Apoptosis in Hepatocellular Carcinoma Cells Involves Enhancing Oxidative Stress Coincident with Activation of Intrinsic and Extrinsic Apoptotic Pathway[J].J Agric Food Chem,2011,59(20):10943-10954.
• [41]Song T Y,Hsu S L,Yen G C.Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture[J].Journal of Ethnopharmacology,2005,100(1-2):158-167.
• [42]Lin Y W,Chiang B H.4-Acetylantroquinonol B Isolated from Antrodia cinnamomea Arrests Proliferation of Human Hepatocellular Carcinoma Hep G2 Cell by Affecting p53,p21 and p27 Levels[J].JAgric Food Chem,2011,59(16):8625-8631.
• [43]Lin Y W,Pan J H,Liu R H,et al.The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells[J].Jsci Food Agric,2010,90(10):1739-1744.
• [44]Lee I H,Huang R L,Chen C T,et al.Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects[J].FEMS Microbiology Letters,2002,209:63-67.
• [45]Do Thi Phuong,Chao-Mei Ma,Masao Hattori,et al.Inhibitory Effects of Antrodins A-E from Antrodia cinnamomea and Their Metaboliteson Hepatitis C Virus Protease[J].Phytother Res,2009,23:582-584.
• [46]Wen-Chuan Lin,Shu-Ching Kuo,Wei-Li Lin,et al.Filtrate of fermented mycelia from Antrodia camphoratareduces liver fi brosis induced by carbon tetrachloride in rats[J].World J Gastroenterol,2006,12(15):2369-2374.
• [47]Wu M T,Tzang B S,Chang Y Y,et al.Effects of Antrodia camphorata on Alcohol Clearance and Antifibrosis in Livers of Rats Continuously Fed Alcohol[J].Journal of Agricultural and Food Chemistry,2011,59:4248-4254.
• [48]Huang C H,Chang Y Y,Liu C W,et al.Fruiting Body of Niuchangchih(Antrodia camphorata)Protects Livers against Chronic Alcohol Consumption Damage[J].Journal of Agricultural and Food Chemistry,2010,58:3859-3866.
• [49]Lu Z M,Tao W Y,Zou X L,et al.Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats[J].Journal of Ethnopharmacology,2007,110:160-164.
• [50]Huang C H,Chang Y Y,Liu C W,et al.Fruiting Body of Niuchangchih(Antrodia camphorata)Protects Livers against Chronic Alcohol Consumption Damage[J].Journal of Agricultural and Food Chemistry,2010,58:3859-3866.
• [51]Wang G J,Tseng H W,Chou C J,et al.The vasorelaxation of Antrodia camphorata mycelia:Involvement of endothelial Ca2+-NO-c GMP pathway[J].Life Sciences,2003,73:2769-2783.
• [52]Liu D Z,Liang Y C,Lin S Y,et al.Antihypertensive Activities of a Solid-State Culture of Taiwanofungus camphoratus(Chang-Chih)in Spontaneously Hypertensive Rats[J].Biosci.Biotechnol.Biochem,2007,71(1):23-30.
• [53]Chien S C,Chen M L,Kuo H T,et al.Anti-inflammatory Activities of New Succinic and Maleic Derivatives from the Fruiting Body of Antrodia camphorata[J].Journal of Agricultural and Food Chemistry,2008,56:7017-7022.
• [54]Meng L M,Pai M H,Liu J J,et al.Polysaccharides from extracts of Antrodia camphorata mycelia and fruiting bodies modulate inflammatory mediator expression in mice with polymicrobial sepsis[J].Nutrition,2012,28:942-949.
• [55]Shen Y C,Chou C J,Wang Y H,et al.Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species[J].FEMS Microbiology Letters,2004,23:137-143.
• [56]Hseu Y C,Wu F Y,Wu J J,et al.Anti-inflammatory potential of Antrodia Camphorata through inhibition of i NOS,COX-2 and cytokines via the NF-κB pathway[J].International Immunopharmacology,2005,5:1914-1925.
• [57]Lu Z M,Xu Z H.Antcin A contributs to anti-inflammatory effect of Niuchangchih(Antrodia camphorata)[J].Acta Pharmacol Sin,2011,32(8):981-982.
• [58]Chen Y C,Liu Y L,Li F Y,et al.Antcin A,a steroid-like compound from Antrodia camphorata,exerts anti-inflammatory effect via mimicking glucocorticoids[J].Acta Pharmacol Sin,2011,32:904-911.
• [59]单丽珠,宋腾,王华庆.牛樟芝联合化疗对恶性肿瘤患者免疫功能影响[J]中国中西医结合外科杂志,2015,6:552-555.
• [60]张东柱.台湾特有珍贵药用真菌牛樟芝[J].食药用菌,2011,19(1):33-34.
• [61]苏庆华.健康的守护神国宝樟芝[M].台北市:爱克思文化事业有限公司,2002:60-64.