鸡血藤化学成分研究Study on Chemical Constituents of Spatholobus Suberectus Dunn
翟明,刘军民
ZHAI Ming,LIU Junmin
摘要(Abstract):
目的研究鸡血藤的化学成分,为该药材的开发利用和质量评价提供依据。方法采用各种色谱技术进行分离纯化,通过理化常数测定和波谱分析进行化学成分分析。结果从鸡血藤中又分离得到5个化合物,其结构鉴定为:正二十七烷酸(Ⅰ)、3,7-二羟基-6-甲氧基二氢黄酮醇(Ⅱ)、芒柄花素(Ⅲ)、β-谷甾醇(Ⅳ)、4',8-二甲氧基-7-O-β-D-葡萄糖基异黄酮(Ⅴ)。结论化合物4',8-二甲氧基-7-O-β-D-葡萄糖基异黄酮为首次在鸡血藤植物中发现。
OBJECTIVE To investigate the chemical constituents of Spatholobus suberectus dunn,and to provide evidence for the development and utilization and quality of the mederial. METHODS The chemical constituents were isolated and purified by various chromatographic methods, and their spectral features were analyzed by physicochemical properties and spectral data analyses.RESULTS Five compounds were isolated from Spatholobus suberectus dunn,and they were 27 alkylacid( Ⅰ),3,7-dihydroxy-6-methoxy Dihydroflavonol( Ⅱ), formononetin( Ⅲ), β-sitosterol( Ⅳ),4',8-dimethoxy-7-O-β-D-glucosyl is oflavones( Ⅴ).CONCLUSION Compound Ⅴ were found for the first time in Spatholobus suberectus dunn.
关键词(KeyWords):
鸡血藤;豆科;化学成分
Spatholobus suberectus dunn;Leguminosae;chemical constituents
基金项目(Foundation): 广东省科技计划项目(2007A032200001);; 广东省教育部科技部企业科技特派员行动计划专项(2009B090600135);; 梅州市科技计划项目(2013B36)
作者(Author):
翟明,刘军民
ZHAI Ming,LIU Junmin
参考文献(References):
- [1]赵学敏.本草纲目拾遗[M].人民卫生出版社.1983:229-231.
- [2]国家药典委员会编.中华人民共和国药典[M].一部.北京:中国医药科技出版社,2010,180.
- [3]Yan QX,Li P,Wang D.Study on the Liposoluble Components of the Caulis spatholobi[J].Journal Of China Chinese Pharmaceutical University.2001,32(5):336-338.
- [4]严启新,李萍,胡安明.鸡血藤化学成分的研究[J].中草药,2003,34(10):876-878.
- [5]韩丽平.鸡血藤的化学成分研究[J].中国药房.2005,17(20):1596-1598.
- [6]郑岩,刘桦,白焱晶,等.鸡血藤黄酮类化合物的研究[J].中国中药杂志,2008,33(2):152-154.
- [7]富琦,罗晓琴,唐勇,等.鸡血藤提取物体内抗肿瘤效应及对造血功能的影响[J].中国中医药信息杂志,2008,15(12):29-31.
- [8]黄新炜,李宝强,王秀华,等.鸡血藤水提物的镇静、催眠作用研究[J].西安文理学院学报:自然科学版,2009,12(1):62-64.
- [9]王彦志,冯卫生,石任兵,等.野葛中的一个新化学成分[J].药学学报,2007,42(9):964-967.