利福平降低硝苯地平降压疗效的病例分析Case Analysis of Rifampicin Reducing Antihypertensive Effects of Nifedipine
何赛珠,林茵,梁智江
HE Saizhu,LIN Yin,LIANG Zhijiang
摘要(Abstract)：
目的探讨利福平和硝苯地平相互作用和作用机制,强调临床药师在药学监护和药物治疗方案调整中的作用。方法查阅病历资料和相关文献,对1例服用降压药物的患者在抗结核治疗中出现血压波动的病例进行分析讨论。结果利福平可能通过诱导CYP3A4使硝苯地平降压疗效降低。结论抗结核治疗过程中作用相同代谢途径的药物相互作用应引起重视,为此药师参与临床用药实践可使临床用药更加规范、合理,更好地实施个体化用药及监护。
OBJECTIVE To discuss the interactions and mechanism between rifampicin and nifedipine,thus to emphasize the role of clinical pharmacists would play in pharmaceutical care and drug treatments adjustment. METHODS The medication of a tuberculosis patient with unstable hypertension was analyzed by searching the record and related literatures. RESULTS Rifampicin may reduce the antihypertensive effect of nifedipine by the inductive effect on CYP3A4 enzymes.CONCLUSION Interactions among drugs sharing the same metabolism pathway should call attention to tuberculosis treatment,and the practice of pharmacist can make the clinical medication more standardized,reasonable,and better implement individualized medication and care.
关键词(KeyWords)：
利福平;硝苯地平;药物相互作用;药学监护
Rifampicin;Nifedipine;drug interaction;pharmaceutical care
基金项目(Foundation):
作者(Author):
何赛珠,林茵,梁智江
HE Saizhu,LIN Yin,LIANG Zhijiang
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