高剂量阿托伐他汀强化疗法对急性缺血性脑卒中患者治疗预后的影响Effect of High Dose of Atorvastatin on the Prognosis of Patients with Acute Ischemic Stroke
郭新生,易士华,梁继红
GUO Xinsheng,YI Shihua,LIANG Jihong
摘要(Abstract)：
目的研究高剂量阿托伐他汀强化疗法对急性缺血性脑卒中患者治疗预后的影响。方法选取2014年2月~2016年2月某院收治的96例急性缺血性脑卒中患者,随机分为研究组48例及常规组48例。常规组患者用硫酸氢氯吡格雷、奥扎格雷钠等药物治疗;研究组患者在常规治疗的基础上采用高剂量阿托伐他汀强化疗法治疗,评价研究组与常规组的治疗效果,并进行比较分析。结果研究组患者治疗后神经功能缺损、生活活动能力评分以及hs-CRP水平与常规组比较,差异有统计学意义(P<0.05);研究组患者治疗后LDL-C、TC、Cr、ALT水平以及不良反应发生率与常规组比较,差异无统计学意义(P>0.05)。结论高剂量阿托伐他汀强化疗法对急性缺血性脑卒中患者治疗预后的改善有积极作用,值得临床推广应用。
OBJECTIVE To study the effect of high-dose atorvastatin therapy on the prognosis of patients with acute ischemic stroke. METHODS From February 2014 to February 2016,96 patients with acute ischemic stroke were randomly divided into two groups: the study group( 48 cases) and the conventional group( 48 cases). Patients of the conventional group treated with clopidogrel sulfate,ozagrel sodium. And patients of the study group were treated with a high dose of atorvastatin intensive therapy regimen on the basis of conventional therapy. Therapeutic effects of the two groups were evaluated and compared. RESULTS The neurological deficits,the score of living activity and the level of hs-CRP in the study group were significantly different from those in the conventional group( P<0.05). After treatment,LDL-C,TC,Cr,ALT level and the incidence of adverse reactions were not significantly different from the conventional group( P>0.05). CONCLUSION High dose of atorvastatin intensive therapy has a positive effect on the prognosis of patients with acute ischemic stroke,and it is worthy to be widely used clinically.
关键词(KeyWords)：
高剂量;阿托伐他汀;急性缺血性脑卒中
high dose;atorvastatin;acute ischemic stroke
基金项目(Foundation):
作者(Author):
郭新生,易士华,梁继红
GUO Xinsheng,YI Shihua,LIANG Jihong
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