今日药学

2021, v.31(10) 737-740

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HPLC法测定吐泻肚痛胶囊中木香烃内酯、去氢木香内酯、和厚朴酚及厚朴酚的含量
Determination of Costus Lactone, Dehydrocostus Lactone, Honokiol and Magnolol in Tuxiedutong Capsules by HPLC

古炳明;邬伟魁;黄陈赋;刘佳;刘美芳;杨圣南;
GU Bingming;WU Weikui;HUANG Chenfu;LIU Jia;LIU Meifang;YANG Shengnan;Meizhou Institute for Food and Drug Control;Medicine School of Jiaying College;

摘要(Abstract):

目的建立液相色谱方法,同时测定吐泻肚痛胶囊中的木香烃内酯、去氢木香内酯、和厚朴酚及厚朴酚的含量。方法液相色谱条件:Diamonsil Plus C_(18)柱(250 mm×4.6 mm, 5μm),柱温:30℃;检测波长230 nm;流动相:甲醇-水(65∶35);流速:1.0 mL·min(-1);进样量:10μL。结果 4种成分在各自线性范围内关系良好(r(-1);进样量:10μL。结果 4种成分在各自线性范围内关系良好(r2≥0.999),平均加样回收率97.82%~99.74%,RSD为0.65%~1.08%。结论本文所建立的方法可靠方便,专属性强,可以作为该制剂的质量控制方法。
OBJECTIVE To establish a liquid chromatography method to simultaneously determine the content of costanolide, dehydrocostusrolactone, honokiol and magnolol in Tuxiedutong capsules. METHODS HPLC conditions were as follow: Diamonsil Plus C_(18) column(250 mm×4.6 mm, 5 μm). Column temperature: 30 ℃. Detection wavelength 230 nm. Mobile phase: methanol-water(65∶35). Flow rate: 1.0 mL·min2≥0.999),平均加样回收率97.82%~99.74%,RSD为0.65%~1.08%。结论本文所建立的方法可靠方便,专属性强,可以作为该制剂的质量控制方法。
OBJECTIVE To establish a liquid chromatography method to simultaneously determine the content of costanolide, dehydrocostusrolactone, honokiol and magnolol in Tuxiedutong capsules. METHODS HPLC conditions were as follow: Diamonsil Plus C_(18) column(250 mm×4.6 mm, 5 μm). Column temperature: 30 ℃. Detection wavelength 230 nm. Mobile phase: methanol-water(65∶35). Flow rate: 1.0 mL·min(-1). Sample volume: 10 μL. RESULTS The four components had good relationship within their respective linear ranges(r(-1). Sample volume: 10 μL. RESULTS The four components had good relationship within their respective linear ranges(r2≥0.999). The average recovery rate of sample addition was 97.82%-99.74%,and the RSD was 0.65%-1.08%. CONCLUSION The method established in this article is reliable, convenient, and specific, and can be used as a quality control method for the preparation.

关键词(KeyWords): 吐泻肚痛胶囊;木香烃内酯;去氢木香内酯;厚朴酚;和厚朴酚
Tuxiedutong capsules;costuslactone;dehydrocostuslactone;magnolol;honokiol

Abstract:

Keywords:

基金项目(Foundation): 梅州市科技计划项目(201118172052301)

作者(Authors): 古炳明;邬伟魁;黄陈赋;刘佳;刘美芳;杨圣南;
GU Bingming;WU Weikui;HUANG Chenfu;LIU Jia;LIU Meifang;YANG Shengnan;Meizhou Institute for Food and Drug Control;Medicine School of Jiaying College;

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