硝普钠在豚鼠离体气管螺旋条中的舒张作用Relaxing effect of sodium notroprusside on guinea pig isolated trachea spiral strip
李荣,张珍祥
Li Rong(Shenzhen Longgang Central Hospital;Guangdong 518116) Zhang Zhenxiang(Respiratory disease research laboratory;
摘要(Abstract)：
目的 :研究硝普钠 (SNP)在豚鼠离体气管螺旋条中舒张作用的机制。方法 :在浴槽内加入硝普钠从10 - 7M至 10 - 3M ,观察气管螺旋条张力的变化 ,并检测浴槽中NO ,气管螺旋条组织cAMP、cGMP的变化。结果 :加入硝普钠气管螺旋条张力下降 ,浴槽内NO增加 ,气管螺旋条组织cAMP、cGMP增加。结论 :硝普钠有舒张气管螺旋条的作用 ,推测是通过NO cGMP系统发挥作用
Objective: To evaluate the role of sodium notroprusside(SNP)on the guinea pig isolated trachea spiral strip. Methods: Adding SNP in the organ both from 10 -7 M to 10 -3 M ,the tension and cAMP?cGMP of isolated trachea spiral strip,and the nitric oxide in organ both were observed.Results: After adding SNP,the tension of isolated trachea spiral strip increased,the nitric oxide in organ both and cAMP?cGMP in isolated trachea spiral strip increased.Conclusion: SNP could relax the guinea pig isolated trachea spiral strip,it may be though NO cGMP system.
关键词(KeyWords)：
豚鼠离体气管螺旋条;硝普钠
Guinea pig isolated trachea spiral strip ;SNP
基金项目(Foundation):
作者(Authors):
李荣,张珍祥
Li Rong(Shenzhen Longgang Central Hospital;Guangdong 518116) Zhang Zhenxiang(Respiratory disease research laboratory;
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