今日药学

2009, v.19(12) 35-37

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两组免疫抑制方案用于肾移植术后的对比研究
Comparison of Two Immunosuppressive Schemes Used in Renal Rransplant Recipients

唐波;叶丽卡;王若伦;李伟;许华佟;
TANG Bo1,YE Li-ka1,WANG Ruo-lun1,LI Wei2,XU Hua-tong3(1.The Second Affiliated Hospital of Guangzhou Medical College Guangzhou,Guangdong 510260,China;2.Armed Police Hospital of Guangdong Province Guangzhou,Guangdong 510000,China;3.Guangdong Pharmaceutical University,Guangzhou,Guangdong 510006,China)

摘要(Abstract):

目的比较肾移植患者术后应用他克莫司(FK506)或环孢素A(CsA)为基础的2种免疫抑制方案的疗效和安全性。方法肾移植患者57例分成2组,FK506组为25例,CsA组为32例。观察肾移植后1年内两组的急性排斥发生率、药物性肝肾损害发生率、血糖异常及感染的发生情况。结果两组免疫抑制方案在肝肾损害发生率、感染发生率以及对血糖的影响方面差异无统计学意义。结论两种免疫抑制方案在肾移植术后具有同样的临床应用价值。
ObjectiveTo compare the effect and safety of 2 elementary immunosuppressive schemes based on FK506 and CsA in patients after renal transplant.Methods A total of 57 cases of kidney transplant recipients were divided into 2 groups:Group A (n=25) treated with FK506;Group B (n=32) treated with CsA.The follow-up period was at least 1 year.The end-points of observation included acute rejection,and reversal rate of after immunosuppressive drugs bolus,hepatotoxicity,renal impairment,hyperglycosemia and infection rates in the 2 groups.Results Two immunosuppressive schemes make no difference in acute rejection,hepatotoxicity,renal impairment,hyperglycosemia and infection rates.Conclusion Two immunosuppressive schemes have the same value of clinical practice.

关键词(KeyWords): 他克莫司;环孢素;肾移植;免疫抑制剂
Tacrolinus;Cyclosprorine;renal transplant;Immunosuppressive agents

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作者(Author): 唐波;叶丽卡;王若伦;李伟;许华佟;
TANG Bo1,YE Li-ka1,WANG Ruo-lun1,LI Wei2,XU Hua-tong3(1.The Second Affiliated Hospital of Guangzhou Medical College Guangzhou,Guangdong 510260,China;2.Armed Police Hospital of Guangdong Province Guangzhou,Guangdong 510000,China;3.Guangdong Pharmaceutical University,Guangzhou,Guangdong 510006,China)

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