今日药学

2010, v.20(07) 37-39+66

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呼吸病区2003~2008年抗菌药物使用量与铜绿假单胞菌耐药相关性的研究
Analysis of Correlation between Consumption of Anti-bacterial Agents and Resistance Rate of Pseudomonas Aeruginosa in Respiratory Unit

杨新云;卓超;叶枫;钟淑卿;袁锦屏;杨灵;
YANG Xin-yun1,ZHUO Chao2,YE Feng2,ZHONG Shu-qing2,YUAN Jin-ping2,YANG Ling2(1.The First Affiliated Hospital of Guangzhou Medical College,Guangzhou,Guangdong 510120,China;2.Guangzhou Institute of Respiratory Disease,Guangzhou,Guangdong 510120,China)

摘要(Abstract):

目的探讨2003~2008年呼吸病区抗菌药物使用与铜绿假单胞菌(PA)耐药水平变化之间的关系。方法计算10种抗菌药物平均每日每百张床位所消耗的DDDs及同期PA的耐药率,并对抗菌药物用量与耐药率进行相关性分析。结果头孢他啶及头孢哌酮/舒巴坦DDDs分别与铜绿假单胞菌对哌拉西林、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、亚胺培南、环丙沙星、阿米卡星耐药率的相关性有统计学意义,其他组数据无统计学意义。结论呼吸病区头孢他啶及头孢哌酮/舒巴坦DDD s的使用量与PA耐药率有统计学意义。
Objective To investigate the relationship between administration of anti-bacterial agents and resistance rate of Pseudomonas aeruginosa(PA) in the respiratory unit. Methods The defined daily doses(DDD) /day/100 bed of the 10 kinds of anti-bacterial was calculated;and the resistance rate of PA at that period was collected;and their correlation was analyzed.Results There was a significant positive correlation between the consumption of ceftazidime cefoperazone-Sulbactam and the resistance rate of PA of ceftazidime,cefoperazone-sulbactam,imipenem,ciprofloxacin,and amikacin.Conclusion There is a significant correlation between the consumption of anti-bacterial agents and resistance rate of PA in the respiratory unit.

关键词(KeyWords): 铜绿假单胞菌;耐药率;抗菌药物使用频度
pseudomonas aeruginosa;drug resistance;consumption of anti-bacterial agents

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基金项目(Foundation): 广州市卫生局基金资助(编号:2006-YB-158)

作者(Author): 杨新云;卓超;叶枫;钟淑卿;袁锦屏;杨灵;
YANG Xin-yun1,ZHUO Chao2,YE Feng2,ZHONG Shu-qing2,YUAN Jin-ping2,YANG Ling2(1.The First Affiliated Hospital of Guangzhou Medical College,Guangzhou,Guangdong 510120,China;2.Guangzhou Institute of Respiratory Disease,Guangzhou,Guangdong 510120,China)

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