今日药学

2018, v.28(06) 395-399

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

曲安奈德苯海拉明水杨酸酊质量标准提高研究
Study on Improving the Quality Standard of Triamcinolone Diphenhydramine Salicylic Acid Tincture

刘丹;林颖苹;李志平;何皎;宫灿仪;
LIU Dan;LIN Yingping;LI Zhiping;HE Jiao;GONG Canyi;Dermatosis Hosiptal of Southern Medical University;Huizhou Institute of Dermatology;

摘要(Abstract):

目的为了控制医院制剂的质量,改进质量控制方法,提高曲安奈德苯海拉明水杨酸酊的质量标准。方法参照相关文献,探索适合的含量测定方法。采用高效液相色谱(HPLC)法同时测定醋酸曲安奈德、盐酸苯海拉明、水杨酸的含量,采用气相色谱(GS)法同时测定薄荷脑、苯酚的含量。结果醋酸曲安奈德在0.007 28~0.011 648 mg·m L~(-1)浓度范围内呈良好的线性关系,r=0.999 96,平均回收率为101.0(n=9,RSD=1.18%);盐酸苯海拉明在0.118 3~1.902 90 mg·m L~(-1)浓度范围内呈良好的线性关系,r=0.999 98,平均回收率为101.2%(n=9,RSD=1.05%);水杨酸在0.114 86~1.837 76 mg·m L~(-1)浓度范围内呈良好的线性关系,r=0.999 94,平均回收率为100.1%(n=9,RSD=1.30%);薄荷脑在0.129 5~2.072 5 mg·m L~(-1)浓度范围内呈良好的线性关系,r=0.999 93,平均回收率为100.0%(n=9,RSD=0.18%);苯酚在0.118 2~1.891 5 mg·m L~(-1)浓度范围内呈良好的线性关系,r=0.999 95,平均回收率为99.9%(n=9,RSD=0.14%)。结论所建立的含量测定方法简单、易行,重现性好,专属性强,可用于曲安奈德苯海拉明水杨酸酊的质量控制。
OBJECTIVE To effectively control the quality of hospital preparations,to improve the method of quality control and the quality standard of Triamcinolonie Diphenhydramine Salicylic Acid Tincture. METHODS According to the China Pharmacopoeia and related literature,the processing method for the sample was explored. The contents of triamcinolone acetonide,diphenhydramine hydrochloride 1 and salicylic acid were determined by HPLC. The contents of menthol and phenol were determined by gas chromatography. RESULTS Triamcinolone acetonide had a good linearity in the range of 0. 007 28-0. 011 648 mg·m L~(-1)( r =0.999 96),the average recovery was 101.0%,with RSD = 1.18%; Diphenhydramine hydrochloride had a good linearity in the range of0.11 893~(-1).902 90 mg·m L~(-1)( r= 0.999 98),the average recovery was 101.2%,with RSD= 1.05%; Salicylic acid had a good linearity in the range of 0.11 486~(-1).837 7 mg·m L~(-1)( r = 0.999 94),the average recovery was 100.1%,with RSD = 1.30%; Menthol had a good linearity in the range of 0.1295-2.0725 mg·m L~(-1)( r = 0.999 93),the average recovery was 100.0%,with RSD = 0.18%; Phenol had a good linearity in the range of 0. 118 2~(-1). 891 5 mg·m L~(-1)( r = 0. 999 95); the average recovery was 99. 9%,with RSD = 0. 14%.CONCLUSION This method is simple with good specificity and reproducibility. It can be used for the quality control of Triamcinolone Diphenhydramine Salicylic Acid Tincture.

关键词(KeyWords): 曲安奈德苯海拉明水杨酸酊;含量测定;高效液相色谱;气相色谱
Triamcinolone Diphenhydramine Salicylic Acid Tincture;concent determination;HPLC;GC

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘丹;林颖苹;李志平;何皎;宫灿仪;
LIU Dan;LIN Yingping;LI Zhiping;HE Jiao;GONG Canyi;Dermatosis Hosiptal of Southern Medical University;Huizhou Institute of Dermatology;

Email:

DOI:

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享