徐晓梅,谭本仁,郑锦坤,邓翔
XU Xiaomei,TAN Benren,ZHENG Jinkun,DENG Xiang

• 1:汕头大学医学院附属粤北人民医院

摘要(Abstract)：

目的观察抗病毒清热口服液联合炎琥宁注射液治疗手足口病的临床疗效。方法将我院2013年1月至2015年10月儿科217例感染柯萨奇A16型等病毒患者随机分为治疗组和对照组,对照组107例每日给予炎琥宁注射液(5~10 mg·kg~(-1),加入5%葡萄糖注射液100~250 mL)静脉滴注治疗;治疗组110例在对照组治疗基础上再给予抗病毒清热口服液治疗。观察两组患儿治疗后的疗效、退热时间、疱疹和皮疹开始消退时间及住院时间等情况。结果治疗组患儿的平均痊愈时间(5.4 d)显著低于对照组(7.7 d),治疗组患儿的退热时间、口腔疱疹开始消退时间和皮疹开始消退时间也显著低于对照组,差异有统计学意义(P<0.05);治疗组的痊愈率(84.5%)显著高于对照组的痊愈率(55.1%),两组疗效的有效率分别为96.4%和90.7%,差异均有统计学意义(P<0.05)。结论抗病毒清热口服液联合炎琥宁治疗儿童手足口病临床效果显著,能提高患儿痊愈率并缩短治疗时间及住院时间。
To observe the clinical effect effect of Kangbingdu Qingre Oral Liquid combined with Yanhuning injection on Coxsackie A16 virus. METHODS A total of 217 patients infected with Coxsackie A16 virus from Jan. 2013 to Oct. 2015 were randomly divided into treatment group( n = 110) and control group( n = 107). Patients in control group were treated with Yanhuning injection( 5-10 mg·kg~(-1)in 5% glucose injection 100-250 mL). Patients in treatment group were treated with Yanhuning injection combined with Kanbingdu Qingre. The curative effect,average cooling time,herpes and rash subsided time,and time of hospitalization were observed. RESULTS The average recovery time of the treatment group( 5.4 d) was significantly lower than the control group( 7.7 d),the average cooling time,herpes and rash subsided time of the treatment group was significantly lower than that of the control group( P<0.05). The cure rate of the treatment group( 84. 5%) was significantly higher than that of the control group the cure rate( 55.1%).THere was significant difference on total effective rate between the treatment group( 96.4%) and the control group( 90.7%).CONCLUSION Kangbingdu Qingre Oral Liquid combined with Yanhuning treatment has significant effect on hand-foot-and-mouth disease,can significantly improve the cure rate in children,shorten the treatment time and hospital stay.

关键词(KeyWords)： 抗病毒清热口服液;炎琥宁注射液;手足口病;柯萨奇A16型病毒
Kangbingdu Qingre Oral Liquid;Yanhuning Injection;Hand-foot-and-mouth Disease;Coxsackie A16 Virus

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 徐晓梅,谭本仁,郑锦坤,邓翔
XU Xiaomei,TAN Benren,ZHENG Jinkun,DENG Xiang

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