今日药学

2019, v.29(02) 93-96

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参芪平喘颗粒提取工艺研究
Study of Extraction Processes in Shenqipingchuan Granules

冯健英;王洛临;李智勇;徐文杰;陈雪婷;李洁环;莫平莉;卢泳;
FENG Jianying;WANG Luolin;LI Zhiyong;XU Wenjie;CHEN Xueting;LI Jiehuan;MO Pingli;LU Yong;Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine/Guangdong Provincial Key Laboratory of Research and Development in TCM;Guangzhou University of Chinese Medicine;

摘要(Abstract):

目的优选参芪平喘颗粒最佳提取工艺。方法以毛蕊异黄酮葡萄糖苷含量为考察指标,通过单因素试验确定煎煮次数、加水量、煎煮时间的3个因素水平;以毛蕊异黄酮葡萄糖苷含量和固形物得率的综合评分值为指标,按照上述单因素试验优选的因素水平进行正交试验,筛选出参芪平喘颗粒的最佳提取工艺。结果最佳提取工艺为处方药材加10倍量水提取2次,每次1.5 h。结论该提取工艺稳定可行,并能较好的保证制剂质量。
OBJECTIVE To optimize the extraction technology of Shenqipingchuan Granules. METHODS With the contents of calycosin-7-glucoside as index,single factor tests were used to choose separately three levels of examine times of extraction,amount of water,extraction time.With the comprehensive scores of the contents of calycosin-7-glucoside and dry extract as index,L9( 3~4) orthogonal design was used to adopted examine times of extraction,amount of water,extraction time. RESULTS The optimical extraction technology conditions were as follows.All herbs were boiled with ten-folds amount water of herbs and extracted for two times,1 h each time. CONCLUSION This extraction process is stable and practical,and can well guarantee the quality of preparation.

关键词(KeyWords): 参芪平喘颗粒;毛蕊异黄酮葡萄糖苷;提取工艺;单因素试验;正交试验
Shenqipingchuan Granules;calycosin-7-glucoside;extraction technology;single factor test;orthogonal design

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基金项目(Foundation): 广东省省级科技计划项目(2017A070701017)

作者(Author): 冯健英;王洛临;李智勇;徐文杰;陈雪婷;李洁环;莫平莉;卢泳;
FENG Jianying;WANG Luolin;LI Zhiyong;XU Wenjie;CHEN Xueting;LI Jiehuan;MO Pingli;LU Yong;Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine/Guangdong Provincial Key Laboratory of Research and Development in TCM;Guangzhou University of Chinese Medicine;

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