谢守霞,张万帆,李江林
XIE Shou-xia ;ZHANG Wang-fan ; LI Jiang-lin (Dept. of Pharmacy;

• 1:暨南大学医学院附属第二医院
• 2:暨南大学医学院附属第二医院
• 3:暨南大学医学院附属第二医院 深圳市人民医院广东深圳518020
• 4:深圳市人民医院广东深圳518020

摘要(Abstract)：

目的　观察银杏叶提取物对大鼠肾脏缺血再灌注损伤的保护作用。方法　将 34只健康雄性SD大鼠随机分为假手术对照组、肾脏缺血再灌注组、银杏叶提取物处理组。肾脏缺血再灌注组、银杏叶提取物处理组肾缺血 1h再灌注 2 4h ,测定血清肌酐 (Cr)、肾组织丙二醛 (MDA)、超氧化物歧化酶 (SOD)变化。结果　银杏叶提取物处理组与肾脏缺血组相比明显降低MDA含量 (P <0 .0 5 ) ,明显升高SOD活性 (P <0 .0 1) ,血肌酐无明显升高 (P <0 .0 5 )。结论　银杏叶提取物通过抗氧化 ,对急性肾缺血再灌注损伤有保护作用
Objective To study the effects of ginkgo biloba extract (EGb761) on renal ischemia reperfusion in rats. Methods Thirty-four rats were divided randomly into the sham operative control group,renal ischemia reperfusion injury group and EGb761-treated group.The renal artery was clasped for 1 hour and then reperfusion 24 hours in renal ischemia reperfusion injury group and EGb761-treated group. The changes of MDA,SOD in kideny and creatinine(Cr) in serum were determined. Results Compared with renal ischemia reperfusion injury group,the content of MDA in EGb761-treated group decreased significantly (P<0.05) and SOD increased sharply (P<0.01);the amount of Cr was decreased (P<0.05). There were no significant differences between the sham operative control group and EGb761-treated group (P>0.05). Conclusion The results indicated that EGb761 could protect kidney function in ischemia reperfusion injury by antioxidant effects.

关键词(KeyWords)： 银杏叶提取物;缺血再灌注;肾损伤
ginkgo biloba extract; ischemia-reperfusion; kidney injury

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 谢守霞,张万帆,李江林
XIE Shou-xia ;ZHANG Wang-fan ; LI Jiang-lin (Dept. of Pharmacy;

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