某院奥沙利铂不良反应报告分析Analysis on ADR Case Reports of Oxaliplatin in A Hospital
郑瑜,李仰康,朱志伟,郑志伟
ZHENG Yu,LI Yangkang,ZHU Zhiwei,ZHENG Zhiwei
摘要(Abstract)：
目的探讨本院奥沙利铂药物不良反应(ADR)发生的特点及规律,为临床安全用药提供参考。方法收集本院2006-12~2015-06发生奥沙利铂ADR的病例,分别从患者的性别、年龄、原患疾病、联合用药、ADR所累及器官或系统及临床表现、过敏反应、ADR的分级及转归等进行统计、分析。结果 60例ADR中男性35例,女性25例;40岁以上中老年人占68.33%;60例病例均有联合用药;皮肤及其附件损害最为常见,占53.10%;ADR主要以过敏反应为主,有53例,占88.33%。结论临床应根据奥沙利铂ADR发生的特点及规律、药物相互作用、配伍禁忌,做好相应的防治措施,以保证用药安全。
OBJECTIVE To investigate the laws and characteristics of adverse drug reactions( ADR) of oxaliplatin occurred in the hospital,and to provide references for safe clinical drug application. METHODS A total of 60 cases with ADR of oxaliplatin were collected from Dec. 2006 to Jun. 2015 in the hospital. The age and sex,diagnosis,combined medication,ADR-involved organs or systems,clinical manifestations,allergic reaction,ADR grading and prognosis of the patients were analyzed. RESULTS In all of the60 ADR cases,35 were male and 25 were female. The incidence of ADR occurred in the patients with the age after 40 was 68.33%. All60 cases had combined medication. The damage to skin and appendant was the most common with a rate of 53.10%. ADR was mainly allergic reaction,and there were 53 cases with a rate of 88.33%.CONCLUSION Clinicians should do corresponding prevention and control measures,according to the characteristics and regularity of oxaliplatin ADR,drug interactions,and incompatibility,to ensure its safe application.
关键词(KeyWords)：
奥沙利铂;药物不良反应;分析;安全用药
Oxaliplatin;ADR;analysis;safe application of drugs
基金项目(Foundation):
作者(Author):
郑瑜,李仰康,朱志伟,郑志伟
ZHENG Yu,LI Yangkang,ZHU Zhiwei,ZHENG Zhiwei
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