葡萄内酯研究进展Research Progress of Auraptene
王艳霓,张建康,叶喜德
WANG Yanni,ZHANG Jiankang,YE Xide
摘要(Abstract):
葡萄内酯为枳壳及其栽培变种所提取分离得到的一种具有多种生物活性化合物。文献表明,该成分在天然植物中含量较少,但抗痴呆活性作用明显。因此,深入研究葡萄内酯意义重大。为此,本文对葡萄内酯近年来研究进展情况进行了文献综述,希望为深入研究提供参考。
Auraptene extracted from Fructus aurantii and cultivated varieties have a variety of biologically active compounds. Based on preliminary studies,it was shown that the concentration of auraptene in natural plants is less. However,auraptene has signifcant anti dementia effect. So further study on auraptene would be very significance. Therefore,the research progress of auraptenein in recent years was reviewed,so as to provide reference for its further research.
关键词(KeyWords):
葡萄内酯;化学成分;药理作用
auraptene;chemical constituents;pharmacological action
基金项目(Foundation): 江西省高等学校教学改革研究省级课题(JXJG-14-12-19);; 江西省卫生厅中医药科研基金(2013A031);; 江西中医药大学校基金(ZX1014)
作者(Author):
王艳霓,张建康,叶喜德
WANG Yanni,ZHANG Jiankang,YE Xide
参考文献(References):
- [1]罗小泉,杨武亮,周至明,等.中药枳壳药材的研究概况[J].江西中医学院学报,2006,18(2):45-47.
- [2]孙星衍,孙冯翼辑.神农本草经(排印本)[M].北京:商务印书馆,1984,80.
- [3]Zhou DY,Xu Q,Xue XY,et al.Rapid qualitative and quantitative analyses of flavanone aglycones in Fructus aurantii by HPLC ion-trap MS[J].J Sep Sci,2007,30(6):858-867.
- [4]曾宪仪,陈小红,肖鸣,等.HPLC法测定枳壳、枳实中辛弗林和N-甲基酪胺的含量[J].中国中药杂志,1997,22(6):362-363.
- [5]叶喜德,黄兆胜,杨武亮,等.枳壳中葡萄内酯提取工艺研究[J].时珍国医国药,2012,23(9):2136-2138.
- [6]张普照,黎艳刚,杨武亮,等.葡萄内酯和马尔敏的合成及活性研究[J].时珍国医国药,2010,21(8):1851-1853.
- [7]杨秀伟,徐波,冉福香,等.40种香豆素类化合物对人胃癌细胞株BGC和人肝癌细胞株BEL-7402细胞生长抑制活性的筛选[J].中国现代中药,2006,8(11):7.
- [8]Mori H,Niwa K,Zheng Q,et al.Cell proliferation in cancer prevention;effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cell[J].Mutation Research,2001,480:201-207.
- [9]K awabata K,Murakami A,Ohigashi H.Citrus auraptene targets translation of MMP-7(matrilysin)via ERK1/2-dependent and mT OR-independent mechanism[J].FEBS Letters,2006,580(22):5288-5294.
- [10]Epifano F,Molinaro G,Genovese S,et al.Neuroprotective effect of prenyloxycoumarins from edible vegetables[J].Neuroscience Letters,2008,443(2):57-60.
- [11]Kuroyanagi K,Kang MS,Goto T,et al.Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in3T3-L1adipocytes[J].Biochemical and Biophysical Research Communications,2008,366(1):219-225.
- [12]涂明珠,肖移生,杨武亮,等.枳壳活性成分对人神经母细胞瘤株SH-SY5Y生长的影响[J].江西中医学院学报,2010,22(3):41-43.
- [13]陈海芳,罗小泉,杨武亮,等.葡萄内酯对东茛菪碱致学习记忆障碍大鼠的影响[J].中国医院药学杂志,2014,34(3):167-170.
- [14]陈海芳,骆利平,杨武亮,等.葡萄内酯对脑缺血致血管性痴呆大鼠的保护作用[J].中国新药杂志,2012,21(11):1210-1213.
- [15]张瑜,陈海芳,杨武亮.葡萄内酯对快速老化小鼠SAMP8学习记忆的影响及其机制研究[J].中药新药与临床药理,2011,22(5):498-501.
- [16]Takeda T,Hosokawa M,Takeshita S,et al.A new routine model of accelerated senescence[J].Mcch Aging,1981,17:183-194.
- [17]Okuma Y,Nomura Y.Senescence aceeleratod moll(SAM)all animal model of senile dementia:pharmacological,neurochemical and molecular biological approach[J].Pharmacology,1998,78:399-404.
- [18]Pilcher J,Sessions G.Mc Bride S/Scopolamine impairs spatial working memory in the radial maze:an analysis by error type and a Hll choice[J].Pharmacol Biochem Behav,1997,58(2):449-459.
- [19]李明,陈海芳,杨武亮,等.葡萄内酯大鼠口服给药后经粪便排泄规律研究[J].江西中医学院学报,2011,23(2):70-71.
- [20]袁金斌,王发英,杨武亮.大鼠静注葡萄内酯的药代动力学研究[J].中国实验方剂学,2011,17(18):130-133.
- [21]叶喜德,黄兆胜,陈海芳,等.葡萄内酯的安全性药理学研究[J].中药新药与临床药理,2012,23(5):522-526.
- [22]吴谦等.医宗金鉴[M].北京:人民卫生出版社,1957,1808.
- [23]黎艳刚,陈海芳,杨武亮,等.葡萄内酯有关物的鉴定[A].云南省药学大会论文集,2012:32-36.
- [24]黎艳刚,陈海芳,杨武亮,等.气相色谱法测定葡萄内酯中的溶剂残留[J].江西中医学院学报,2009,21(4):43-45.
- [25]杨武亮,余保金,陈海芳,等.葡萄内酯新用途.中国,CN101461803[P].2009-06-24.
- [26]张勤安,高晓群.阿尔茨海默病发病机制研究进展[J].医学研究杂志,2012,41(2):7-10.