许祎,王金平,陈晓蕾
XU Yi,WANG Jingping,CHEN Xiaolei

• 1:深圳市职业病防治院
• 2:深圳市第二人民医院

摘要(Abstract)：

1例86 a女性患者因肺部感染使用亚胺培南西司他丁钠0.5 g,q6 h,用药第4日出现四肢抽搐,换用其他抗菌药物后症状消失,但感染未控制。遂再次使用亚胺培南西司他丁钠,虽减慢滴速,仍出现抽搐症状,但幅度和频度减轻。
A 86-year-old female patient was injected with Imipenem and Cilastatin Sodium( IC) 0. 5 g q6 h because of pulmonary infection,convulsion of the limbs occurred on the fourth day,and disappeared after withdrawal of IC. Several days later,IC was used again because of uncontrolled infection,convulsion of the limbs emerged again in spite of slow drip,but symptom was mild.

关键词(KeyWords)： 亚胺培南西司他丁;药品不良反应;四肢抽搐
Imipenem and Cilastatin;adverse drug reactions;convulsion of the limbs

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 许祎,王金平,陈晓蕾
XU Yi,WANG Jingping,CHEN Xiaolei

参考文献(References)：

• [1]贾朝阳,强万本,魏斌,等.CT表现脑萎缩与癫痫的相关性初探[J].实用医学杂志,2001,17(10):930.
• [2]Stanley LP,David CC,Scott RE,et al.Prospective surveillance of imip-enem-cilastatin use and associated seizure using a hospital information system[J].Ann Phanncother,1993,27(4):497-499.
• [3]Makato S,Haruke M,Yoshihiro S,el al.Structural features resulting in convulsive activity of carbapenem compounds:effect of C-2 side chain[J].J Antibiot,1995,48(5):408-413.
• [4]Zivanovic D,Lovic OS,Susic V.Effects of manipulation of Nmethyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats[J].Indian J Med Res,2004,119(2):79-85.
• [5]薛国珍.1例亚胺培南西司他丁钠引起的神经系统的不良反应分析[J].医学信息,2012,25(9):410.
• [6]伦新强.亚胺培南/西司他丁纳对神经系统的影响及防治[J].药物不良反应杂志,2002,4(1):20.
• [7]乔薇.亚胺培南-西司他丁钠致老年患者痫性发作[J].药物不良反应杂志,2010,12(5):353-354.
• [8]Linden P.Safety profile of meropenem:an updated review of over6 000 patients treated with meropenem[J].Drug Saf,2007,30(8):657-668.