今日药学

2002, (06) 38-39

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灯盏花素治疗抗结核药物性肝损的疗效分析
The effect of breviscapine on liver lesion induced by anti-tuberculosis drugs

孙健,韩展昭,刘琨,顾玉虹,陈慧玉,陈洪光
Sun Jian,Han Zhanzhao.Liu Kun,Gu Yuhong,Chen Huiyu.Chen Hongguang(The Chest Hospital of Guangzhou,Guangzhou 510095)

摘要(Abstract):

目的 了解灯盏花素注射液治疗抗结核药物性肝损的疗效。方法 60例肺结核患者在抗结核治疗过程中出现抗结核药物性肝损,且达到停药标准时,随机分为2组。治疗组30例每天用灯盏花素注射液30ml加入10%的葡萄糖溶液500ml中静脉滴注,对照组30例则以维生素C 2g替代灯盏花素注射液,疗程均为25~30d,以肝功能恢复到正常为治疗有效,观察两组的有效率,用x~2检验两者的差异显著性。结果 实验组治疗药物性肝损有效率83.3%,比对照组50%高(P<0.01)。结论灯盏花素注射液对肝损害有保护作用,用于治疗抗结核药物性肝损是有效的。
Objective To investigat the effect of breviscapine in treatment of liver lesion patients induced by anti-tuberculosis drugs. Methods 60 cases with liver lesion patients induced by anti-tuberculosis drugs, were reached the stopping-treament level. These patients were then randomized into two grougs. The same parameters were treated for 25 ~ 30 days, a treatment group(30 cases) were only given breviscapine, the control group were given vitamini C instead of breviscapine The effective cases were defined by reduce to normal level of SGPT on the liver lesion patients. With two-grups-controlled method, to investigat effect of two groups. Results The effective rate of the treament group were significantly higher than those in control group ( P < 0. 01 ). Conclusion Breviscapine can defend against liver lesion,and it is effective to treat liver lesion induced by anti-tuberculosis drugs.

关键词(KeyWords): 灯盏花素;结核;药物性肝损
breviscapine; tuberculosis; liver lesion induced by drugs

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作者(Author): 孙健,韩展昭,刘琨,顾玉虹,陈慧玉,陈洪光
Sun Jian,Han Zhanzhao.Liu Kun,Gu Yuhong,Chen Huiyu.Chen Hongguang(The Chest Hospital of Guangzhou,Guangzhou 510095)

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