今日药学

2014, v.24(03) 149-151+177

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在体单向肠灌流模型研究槲皮素的大鼠肠吸收特性
Research on Intestinal Absorption Characteristics of Quercetin in Rats by in-situ Single-Pass Perfusion Model

韩珂;谢志红;叶丽卡;
HAN Ke;XIE Zhi-hong;YE Li-ka;The Second Affiliated Hospital of Guangzhou Medical University;

摘要(Abstract):

目的考察银杏中活性黄酮成分槲皮素在大鼠肠道的吸收特性。方法以酚红为标示物,采用在体单向肠灌流模型,HPLC法测定槲皮素在体肠灌流的浓度变化,研究槲皮素在小肠内的吸收情况。结果槲皮素在(1.01~20.18μg/mL)浓度范围内其肠管通透率和血管通透率均基本保持不变,各浓度间无显著性差异(P>0.05)。结论药物浓度对槲皮素通透率无影响,其吸收机制可能为被动扩散。
Objective To investigate the intestinal absorption characteristics of quercetin in rats. Methods The in-situ rat single-pass intestinal perfusion model was used to study the absorption mechanism of quercetin and the effect of drug concentration on the absorption. Results No significant differences in intestinal quercetin permeability values were observed at differernt quercetin inlet concentrations( P > 0. 05). Conclusion Its absorption mechanism of quercetin may be related to passive diffusion.

关键词(KeyWords): 槲皮素;肠灌流;肠吸收;血药浓度
quercetin;intestinal perfusion;intestinal absorption;plasma concentration

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基金项目(Foundation): 广东省药学会医院药学研究基金(编号:2013A24)

作者(Author): 韩珂;谢志红;叶丽卡;
HAN Ke;XIE Zhi-hong;YE Li-ka;The Second Affiliated Hospital of Guangzhou Medical University;

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