改善莫索尼定片含量均匀度的制备工艺研究Study on the preparation technology of moxonidine tablets to improve the uniformity of content
吴少玲
Wu Shaoling(Guangzhou Qiaoguang pharmaceutical factory;
摘要(Abstract)：
目的 解决小剂量药物莫索尼定片含量均匀度不符合规定的问题。方法 先将PVP、L -HPC、乳糖混合均匀 ,莫索尼定以 60 %乙醇溶解后加入 ,利用苋菜红帮助判断制粒过程是否混合均匀。结果 莫索尼定片含量均匀度符合规定。结论 制备工艺可行
Objective To solve the problem that moxonidine tablets do not comply with the test for the uniformity of content.Methods PVP,L HPC and lactose were well mixed first,moxonidine was added after being dissolved in 60% ethanol and amaranth was added to determine whether the granules were well mixed in the process of making granules.Results moxonidine tablets complied with the test for uniformity of content.Conclusion The method is reliable.
关键词(KeyWords)：
莫索尼定;含量均匀度;制备工艺
moxonidine;uniformity of content;preparation technology
基金项目(Foundation):
作者(Authors):
吴少玲
Wu Shaoling(Guangzhou Qiaoguang pharmaceutical factory;