今日药学

2009, v.19(08) 41-42+58

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49株表皮葡萄球菌的耐药分析
Analysis of Drug Resistance of 49 Strains of Staphylococcus Epidermidis

郭静;方静;王德;
GUO Jing1,FANG Jing1,WANG De2(1.Department of Pharmacy,2.Department of Clinical Laboratory,Peking University Shenzhen Hospital,Shenzhen,Guangdong 518036,China)

摘要(Abstract):

目的分析从无菌体液标本中分离出的49株非重复表皮葡萄球菌对不同种类抗生素的耐药性,为临床合理用药提供参考。方法收集临床分离出的49株非重复表皮葡萄球菌,用K-B法进行体外药敏试验,依据美国国家临床试验室标准化协会(CLSI)制定的标准判定药敏结果。结果检出的49株非重复表皮葡萄球菌中耐甲氧西林表皮葡萄球菌(MRSE)的产生率达到83.7%。对头孢唑啉、亚胺培南和阿莫西林/克拉维酸的耐药率都在80%以上,对庆大霉素、环丙沙星、左氧氟沙星的耐药率在60%以上,对表皮葡萄球菌敏感率较高的有氯霉素、利福平、利奈唑胺、万古霉素,其中利奈唑胺和万古霉素均未出现耐药菌株。结论表皮葡萄球菌的耐药情况严重,需加强表皮葡萄球菌的耐药监测,临床应结合药敏结果合理使用抗生素。
Objective To analysis the antibiotics resistance of 49 strains of Staphylococcus epidermidis in our hospital from Jan 2008 to Dec 2008,and to provide reference for rational use of antibiotics.Methods Among the 49 strains of Staphylococcus epidermidis isolated from clinic,the antibiotics susceptibility test was used,and the results were analyzed.Results Meticillin-resistant Se(MRSE) accounted for 83.7% in 49 strains of Staphylococcus epidermidis.The resistance rate of Staphylococcus epidermidis to cefazolin,imipenem,amoxicillin/clavulanate exceeded 80%,the resistance rate to gentanlycin,dprofloxacin and levofloxacin exceeded 60%.All strains were sensitive to vancomycin and linezolid.Conclusion The drug resistance of Staphylococcus epidermidis is serious.The key is to strengthen the monitoring of bacterial resistance.Antibiotics should be used rationally in clinic according to the results of susceptibility test.

关键词(KeyWords): 表皮葡萄球菌;耐药率;抗生素
staphylococcus epidermidis;drug resistance;antibiotics

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作者(Author): 郭静;方静;王德;
GUO Jing1,FANG Jing1,WANG De2(1.Department of Pharmacy,2.Department of Clinical Laboratory,Peking University Shenzhen Hospital,Shenzhen,Guangdong 518036,China)

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