登革热极期并肝损害治疗用药的各因素分析Factors Analysis of Medication on Patients at Critical Period of Dengue Fever with Liver Injury
林曼,周波,王建
LIN Man,ZHOU Bo,WANG Jian
摘要(Abstract)：
目的分析登革热(DF)极期并肝损害治疗用药的各因素。方法选取2014年某病区登革热患者,分析其中处于极期患者的肝损害情况,统计分析肝损程度与疾病治疗各因素的相关性。结果在极期,DF并肝损害发生率80.2%,且住院天数和重症登革热(SD)发生率与未合并肝损害患者相比有显著性差异;SD与典型登革热比较,WBC无显著性差异,ALT差异不明显,但AST差异显著;护肝药物对登革热并肝损害患者治疗效果确定,但与护肝药物品种没有相关性,达到一定治疗效果后,药物使用强度的增加并未加强疗效。结论登革热极期患者要充分考虑肝损,因为肝损程度加重引起住院天数增加,但要预防过度治疗。
OBJECTIVE To analyze the factors of medication on patients at the critical period of dengue fever with liver injury.METHODS All the patients with dengue fever hospitalized in one ward in 2014 were selected,the liver injury situation of those patients at the critical period of dengue fever were analyzed,and the correlation between the level of liver injury and other factors of clinical treatment was analyzed. RESULTS At the critical period of dengue fever,the incidence of liver injury was 80. 2%. It was significantly different in the days of hospitalization and the rate of SD occurrence between patients with and without liver injury.Compared to the common dengue fever,WBC and ALT values of SD were no significant difference,except AST value. Though liver protective drugs made certain medication effect on patients with dengue fever and liver injury,there was no correlation between the medication effect and the class of liver protective drugs,after reaching uncertain effect of medication,the increasing of use intensity wouldn't increase the effect any more. CONCLUSION Liver injury should be considered thoroughly on the patients at the critical period of dengue fever,because the aggravation of liver injury can increase the days of hospitalization. However,over-medication should be prevented.
关键词(KeyWords)：
R97登革热;肝损害;极期;药物强度;药物治疗
dengue fever;liver injury;critical period;drug use intensity;medication
基金项目(Foundation):
作者(Author):
林曼,周波,王建
LIN Man,ZHOU Bo,WANG Jian
参考文献(References)：
- [1]广东省卫生与计划生育委员会.广州市卫生计生委2014年工作总结.http://www.gzmed.gov.cn/rhin_gzmed//xxgk/jhzj/26700.html.
- [2]熊益权,陈清.1978~2014年我国登革热的流行病学分析[J].南方医科大学学报,2014,34(12):1811-1825.
- [3]梁文佳,何剑锋,罗会明,等.广东省2001~2006年流行病学分析[J].华南预防医学,2007,33(5):4-7.
- [4]应若素,王建,洪文昕,等.广东省2014年登革热暴发流行的临床和实验室特点[J].中华传染病杂志,2014,32(12):719-723.
- [5]国家卫生和计划生育委员会.《登革热诊疗指南(2014年第二版)》,2014,10.