阮淑芳,吴小玲
RUAN Shufang,WU Xiaoling

• 1:江门市第三人民医院药剂科
• 2:江门市第三人民医院老年一科

摘要(Abstract)：

目的调查分析某院老年抑郁症住院患者潜在不适当用药情况,为老年患者合理用药提供参考。方法回顾性分析某院67例2014年1月～2018年5月60岁以上抑郁症患者的药物使用情况,并以中国老年人潜在不适当用药目录(2017年版)为依据,对其潜在不适当用药情况进行评估分析。结果 67例患者平均年龄(69.28±6.61)岁,平均用药(5.15±3.60)种。66例服用第二代抗抑郁药,其中艾司西酞普兰使用率最高。抗抑郁药治疗以单药为主,二联用药多选择米氮平。依据中国老年人潜在不适当用药判断标准(2017年版),有61位患者(91.04%)存在PIM,共涉及135例次药物的使用。135例次PIM中,涉及神经系统用药68例次(50.37%),精神药物40例次(29.63%);疾病相关性PIM 19例次(28.36%)。结论老年抑郁症患者PIM发生率高,需加强对其不合理用药情况的评价,以保障老年抑郁症患者的用药安全。
OBJECTIVE To investigate and analyze the potential inappropriate use of drugs in hospitalized patients with depression in our hospital,and to provide reference for the rational use of drugs in elderly patients. METHODS A retrospective analysis of the drug use of 67 patients with depression over 60 years from January 2014 to May 2018 in a hospital was conducted based on the list of potentially inappropriate medications for the elderly in China( 2017 edition).The appropriate drug use was evaluated and analyzed. RESULTS The average age of the 67 patients was( 69.28±6.61) years old,and the average medication was( 5.15±3.60).A total of 66 patients used second-generation antidepressants,of which escitalopram was the mostly used antidepressants were principle treated with single drugs,and mirtazapine was the commonly used combined medication. According to the criteria for the potential inappropriate use of drugs for the elderly in China( 2017 edition),61 patients( 91.04%) had PIM,involving a total of 135 drug use.Among the 135 cases of PIM,68 cases( 50.37%) were used for nervous system,40 cases( 29.63%) were psychotropic drugs,and 19 cases( 28.36%) were disease-related PIM. CONCLUSION The incidence of PIM in elderly patients with depression is high. It is necessary to strengthen the evaluation of irrational drug use to ensure the safety of medication for elderly patients with depression.

关键词(KeyWords)： 抗抑郁药;老年抑郁症;潜在不适当用药;用药安全分析
antidepressant;geriatric depression;potential inappropriate medications;drug safety analysis

Abstract:

Keywords:

基金项目(Foundation): 江门市医疗卫生领域科技计划项目(2018E004)

作者(Author): 阮淑芳,吴小玲
RUAN Shufang,WU Xiaoling

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