今日药学

2015, v.25(09) 639-640+652

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HPLC法同时测定愈酚伪麻片中2种成分的含量
Assay of Guaifenesin and Pseudoephedrine Hydrochloride Tablet by HPLC

梁爱仙,庞发根,刘敏,王铁杰,李玉兰
LIANG Aixian,PANG Fagen,LIU Min,WANG Tiejie,LI Yulan

摘要(Abstract):

目的建立同时测定愈酚伪麻片中盐酸伪麻黄碱和愈创木酚甘油醚的HPLC法。方法采用C18柱,流动相:磷酸三乙胺缓冲液(p H2.6)-乙腈(85∶15),流速1.0 m L/min;检测波长215 nm。结果 2种成分均具有良好的线性关系,回收率符合要求。结论本法可用于愈酚伪麻片的含量测定。
OBJECTIVE To establish a determination method for assay of guaifenesin and pseudoephedrine hydrochloride tablet by HPLC simultaneously. METHODS The column packed with octadecylsilane bonded sillica gel and a mixture of buffer( containing phosphoric acid and triethylamine,p H 2. 6)-acetonitrile( 85∶ 15) was used as the mobile phase,the flow rate was 1. 0 m L / min,and detection wavelength was 215 nm. RESULTS The linear range and recovery of all components were suitable for the determination.CONCLUSION The method is accurate and reliable for the analysis of the tablet.

关键词(KeyWords): 愈酚伪麻;高效液相色谱;含量测定
pseudoephedrine hydrochloride;guaifenesin;HPLC;determination

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作者(Author): 梁爱仙,庞发根,刘敏,王铁杰,李玉兰
LIANG Aixian,PANG Fagen,LIU Min,WANG Tiejie,LI Yulan

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