今日药学

2015, v.25(03) 148-155

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慢性乙型肝炎患者核苷(酸)类药物长期抗病毒治疗的安全性
Safety of Long-Term Anti-Viral Treatment with Nucleos( t ) ide Analogues for Patients with Chronic Hepatitis B

陈小苹;彭劼;谢奇峰;许敏;叶晓光;

摘要(Abstract):

大多数接受核苷(酸)(nucleos(t)ide analogues,NAs)类药物治疗的慢性乙型肝炎(chronic hepatitis B,CHB)患者需要长期治疗,部分患者甚至需要终身治疗,而且患者个体间通常存在明显的差异,因此在临床应用过程中需要密切监测NAs类药物长期治疗的安全性。本文旨在对NAs类药物长期抗病毒治疗的安全性数据进行回顾总结,加强广大临床医师对相关安全性问题的认识,并为临床实践提供指导。
Most chronic hepatitis B( CHB) patients need long-term treatment with nucleos( t) ide analogues( NAs),whereas part of them even need life-long treatment. However,due to heterogeneity of human beings,it is great important to monitor the longterm safety of NAs in the management of patients with chronic hepatitis B in clinical practice. This article aimed to review the safety data of long-term anti-viral treatment with NAs with the expectation to enhance the awareness of clinicians to these issues and support clinical practice.

关键词(KeyWords): 慢性乙型肝炎;核苷(酸)类药物;安全性
chronic hepatitis B;nucleos(t) ide analogues;safety

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作者(Author): 陈小苹;彭劼;谢奇峰;许敏;叶晓光;

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