李丽明,郭洁文,邓志军,符永恒,杨敏,潘竞锵,单綺霞
LI Li-Ming1,GUO Jie-wen1,DENG Zhi-jun2 ,FU Yong-heng3,YANG Min3,PAN Jing-qiang1,SHAN Yi-xia4(1. Guangzhou Hospital of Traditional Chinese Medicine

• 1:广州市中医医院
• 2:广州中医药大学中药学院
• 3:广东省人民医院医学研究中心、广东省心血管病研究所
• 4:中山大学附属博济医院

摘要(Abstract)：

目的研究三七总皂苷(PNS)对急性心肌梗死(AMI)后左心室重构(LVRM)大鼠心功能作用。方法除假手术组外采用结扎大鼠左冠状动脉前降支的方法建立AMI模型,术后24h后随机分为对照组和实验组,连续4周分别灌胃给予生理盐水、福辛普利和PNS低、中、高剂量,观察PNS对病鼠室间隔舒张末期厚度(IVSd)、左心室舒张末期内径(宽度)(LVIDd)、室间隔收缩末期厚度(IVSs)、左心室收缩末期内径(宽度)(LVIDs)、左心室后壁舒张末期厚度(LVPWd)、左心室后壁收缩末期厚度(LVPWs)、左心室射血分数(EF)、左心室收缩百分率(FS)、二尖瓣口舒张早期血流速度(MV)、心率(HR)等反映心功能变化指标的影响。结果PNS中、高剂量组的EF、FS及MV指标均显著提高(P<0.01～0.05)。结论PNS通过提高左心室收缩和舒张功能,降低外周阻力,对病鼠AMI后LVRM心功能有保护和改善作用。
Objective Research on the function of Panax Notoginsenoside(PNS) in improving the cardiac function in rats with acute post-myocardial infarction(AMI) left ventricular remodeling(LVRM). Methods Models of AMI were produced by ligation of left anterior descending coronary artery except the sham-operation group,building rat model of AMI,after 24 hours of postoperative in rats.The rats were randomly divided into control and experimental groups,then respectively gavaged NS,fosinopril group and the low、middle ane high dosage of PNS for four consecutive weeks. The cardiac function index such as Ventricular septal end-diastolic thickness (IVSd),Left ventricular end-diastolic dimension(LVIDd),End-systolic ventricular septal thickness(IVSs),Left ventricular end-systolic diameter (LVIDs),End-diastolic posterior wall thickness of left ventricular(LVPWd),End-systolic posterior wall thickness of left ventricular (LVPWs),Ejection fraction (EF),The percentage of left ventricular systolic(FS),Mitral early diastolic flow velocity mouth(MV),Heart rate(HR) in the rats were observed. Result Compared with the NS group,EF,FS and MV(P<0.01～0.05) can be significantly improved by PNS in middle and high dosage group. Conclusion Treatment with PNS in post AMI LVRM enhanced left ventricular systolic and diastolic function,decreased peripheral resistance,PNS can improve the cardiac function in post AMI LVRM.

关键词(KeyWords)： 三七总皂苷;心肌梗死;心室重构;心功能
panax notoginsenoside(PNS);myocardial infarction;ventricular remodeling;cardiac function

Abstract:

Keywords:

基金项目(Foundation): 广东省社会发展领域科技计划项目(编号:83100);; 广东省中医药局基金(编号:1060060、2008005);; 广东省医院药学研究基金(2009A008);; 广州市中医药中西医结合科研(编号:2008A15)资助

作者(Author): 李丽明,郭洁文,邓志军,符永恒,杨敏,潘竞锵,单綺霞
LI Li-Ming1,GUO Jie-wen1,DENG Zhi-jun2 ,FU Yong-heng3,YANG Min3,PAN Jing-qiang1,SHAN Yi-xia4(1. Guangzhou Hospital of Traditional Chinese Medicine

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