注射用胸腺肽不良反应文献分析Literature Analysis of Adverse Reaction of Injectable Thymosin
陈伟,马金兰
CHEN Wei,MA Jin-lan(Cancer Institute and Hospital Academy of Medical Sciences
摘要(Abstract):
目的探讨注射用胸腺肽不良反应的规律,为避免严重不良反应和合理用药提供依据。方法对1998~2008年报道胸腺肽不良反应的文献进行分析。结果注射用胸腺肽可导致多系统不良反应,最严重为过敏性休克,抢救不及时可造成死亡。结论应严格控制适应症,用药前询问过敏史,皮试,严密监护。
Objective To investigate the law of adverse reaction of injectable thymosin and so as to avoid the serious adverse reaction.Methods The documents about adverse reaction of injectable thymosin reported between 1998 and 2008 were analyzed.Results Injectable thymosin could lead to multi-system adverse reaction including serious allergic shock,which may cause death under delayed remedy.Conclusion The scope of application should be strictly controlled,ask the allergic history of the patients and do a skin test before drug administration,and ward the patient tightly after administration.
关键词(KeyWords):
注射用胸腺肽;不良反应;文献分析
injectable thymosin;adverse reaction;literature analysis
基金项目(Foundation):
作者(Author):
陈伟,马金兰
CHEN Wei,MA Jin-lan(Cancer Institute and Hospital Academy of Medical Sciences
参考文献(References):
- 1王娜,吴纪宁,陈海平,等.胸腺肽31例不良反应分析.中国药房,2004,15(3):174.
- 2.张久聪,董茜,邵彬.胸腺肽α1的作用机制和临床应用.细胞与分子免疫学杂志,2006,22(4):547-549.
- 3程经华,蔡皓东.药源性疾病及其诊治原则.药物不良反应杂志.2002,4(2):114-119.
- 4李明,刘媗婷,雒雅丽.静滴胸腺肽致过敏性休克1例报告.陕西医学杂志,2003,32(1):95-96.
- 5冯亮,池频频,黄玉波.胸腺素引起严重过敏性休克致心跳骤停.药物不良反应杂志,2005,5:371-372.
- 6蒋遐芝.胸腺肽注射液生产工艺的改进.海峡药学,2008,20(9):23-24.
- 7王娜,吴纪宁,陈海平,等.胸腺肽31例不良反应分析.中国药房,2004,15(3):174.