刘达平
LIU Da-ping (The People's Hospital of Lechang

• 1:广东省乐昌市人民医院药剂科

摘要(Abstract)：

目的评价西药和中西药联用的两种铁补充剂富马酸亚铁混悬液及健脾生血颗粒的药理功效区别,为临床选药,合理用药提供依据。方法缺铁模型小鼠分为两组,分别给予不同的铁补充剂,测定其血液中红细胞(RBC)含量,血清中超氧化物歧化酶(SOD)活性,丙二醛(MDA)含量,肝脏的过氧化氢酶(CAT)活性。结果两种铁补充剂在改善缺铁性贫血方面疗效肯定,富马酸亚铁混悬液在提高血液中RBC含量速度方面快于健脾生血颗粒,但是在对SOD,MDA,CAT的影响方面,健脾生血颗粒的作用,强于富马酸亚铁混悬液。结论富马酸亚铁混悬液和健脾生血颗粒疗效确切,各有所长,在临床应用中,利用其各自特长,以期获得更好疗效。
Objective To investigate the difference of pharmacological effect between Jianpishengxue granule and Ferrous Fumarate suspension. Methods The iron-deficiency mouse models were divided into 2 groups, and were treated with 2 kinds of supplements-iron, respectively. The levels of RBC, SOD, MDA in the serum and the levels of CAT in liver were determined. Results Both those 2 kinds of supplements-iron can improve the iron deficiency anemia. The Ferrous Fumarate suspension could significantly increase the content of RBC in serum, much faster than Jianpishengxue granule. While the effect of Jianpishengxue granule on SOD, MDA, CAT is better than Ferrous Fumarate suspension. Conclusion The preparations showed satisfactory effect and have their own advantages. The advantages should be used for obtaining better therapeutic effect in clinic application.

关键词(KeyWords)： 富马酸亚铁混悬液;健脾生血颗粒;铁;药理
Ferrous Fumarate suspension; Jianpishengxue granule; iron; pharmacological study

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘达平
LIU Da-ping (The People's Hospital of Lechang

参考文献(References)：

• [1]刘梅兰,张建平.缺铁性贫血的诊断及治疗[J].中国处方药,2008,2:48-51.
• [2]马海侠.健脾生血颗粒治疗婴幼儿缺铁性贫血的疗效观察[J].儿科药学杂志,2006,12(3):54-55.
• [3]黄登宇,赵春贵,等.高铁制剂对缺铁模型小鼠作用研究[J].中国药物与临床,2003,3(5):409-410.
• [4]沈萍,范秀容,李广武.微生物学实验(第3版)[M].北京:高等教育出版社,1999.90.
• [5]刘秋英,孟庆勇.半叶马尾藻多糖体内抗肿瘤作用及其机制探讨[J].第一军医大学学报,2004,24(4):434-436.
• [6]谢云峰,郑艳燕,等.缺铁性贫血大鼠脂质过氧化的研究[J].广西医科大学学报,2000,17(2):203-205.