今日药学

2014, v.24(05) 357-362

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

拉米夫定联合阿德福韦酯与恩替卡韦单药治疗HBeAg阳性慢性乙型肝炎的Meta分析
Meta-Analysis:Efficacy of Lamivudine Plus Adefovir Combination Therapy versus Entecavir Monotherapy in HBeAg-Positive Chronic Hepatitis B

欧阳仁杰;叶晓光;
OUYANG Ren-jie;YE Xiao-guang;Department of Infection,The Second Affiliated Hospital of Guangzhou Medical University;

摘要(Abstract):

目的比较国内拉米夫定联合阿德福韦酯与恩替卡韦单药治疗e抗原(hepatitis Be antigen,HBeAg))阳性慢性乙型肝炎的疗效。方法检索2008-11~2013-11公开发表的有关拉米夫定联合阿德福韦酯与恩替卡韦单药治疗HBeAg阳性慢性乙型肝炎患者的随机对照临床试验(randomizedcontrolledtrial,RCT)论文,并提取纳入研究的特征信息,运用Revman5.1软件对24、48、96周时的乙型肝炎病毒(hepatitis B virus,HBV)DNA转阴率、谷丙转氨酶(alanine aminotransferase,ALT)复常率、HBeAg阴转率及血清转换率进行分析,并采用检验分析研究间的异质性,以优势比(odds ratio,OR)为疗效分析统计量。结果最终纳入6个RCT,结果示拉米夫定联合阿德福韦酯仅在治疗48、96周时ALT复常率及HBeAg血清转换率高于恩替卡韦单药治疗,而其他比较指标2组均无统计学差异。结论综合目前各项指标来看,拉米夫定联合阿德福韦酯与恩替卡韦单药初治HBeAg阳性慢性乙型肝炎疗效无明显差异,都是可以选择的治疗方案。
Objective To evaluate the efficacy of Lamivudine plus Adefovir combination therapy versus Entecavir monotherapy in HBeAg-positive chronic hepatitis B.Methods Chinese papers(randomized controlled clinical trials) about comparison of efficacy between Lamivudine plus Adefovir combination therapy and Entecavir monotherapy in HBeAgpositive Chronic Hepatitis B patients were searched from November 2008 to November 2013 online.The evaluated index contained undetectable serum HBV DNA,serum ALT normalization,HBeAg loss,and conversion rate.The findings were analyzed by RevMan5.1 software.Results Six eligible trials were included.Meta analysis showed that Lamivudine plus Adefovir was more effective than Entecavir in serum ALT normalization rate and HBeAg conversion rate at week 48 and 96,but the others index had no statistic significances.Conclusion There were no significant difference in efficacy of Lamivudine plus Adefovir combination therapy and Entecavir monotherapy in the treatment of HBeAg-positive chronic hepatitis.They are both right therapeutic schedules.

关键词(KeyWords): 拉米夫定;阿德福韦酯;恩替卡韦;HBeAg阳性;Meta分析
Lamivudine;Adefovir dipivoxil;Entecavir;HBeAg positive;meta analysis

Abstract:

Keywords:

基金项目(Foundation): 中国肝炎防治基金会慢性乙肝科研基金(编号:GHF2012208);; 广东省药学会科学研究基金(编号:2013GRS02)

作者(Author): 欧阳仁杰;叶晓光;
OUYANG Ren-jie;YE Xiao-guang;Department of Infection,The Second Affiliated Hospital of Guangzhou Medical University;

Email:

DOI:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享