对静脉药物配置中心抗肿瘤药用药情况分析Analysis of Antitumor Drugs Application in PIVAS
黎刚,郑师明,刘颂华,黄永英,陈锡均
LI Gang1,ZHENG Shi-ming1,LIU Song-hua1,HUANG Yong-ying1,CHEN Xi-jun2(1.Department of Pharmacy
摘要(Abstract)：
目的调查分析本院静脉药物配置中心(PIVAS)抗肿瘤药的使用情况。方法对本院2007年1月至12月PIVAS配置的抗肿瘤静脉输液医嘱共2 529份进行统计和分析。结果抗肿瘤药医嘱的审核和配制需关注载体选择、用量、给药剂量、给药时间、给药顺序、滴注速度等方面的问题。结论PIVAS先进的静脉配液技术和药师的审核作用,促进抗肿瘤药的合理应用。
Objective To investigate the application of antitumor drugs of pharmacy intravenous admixture services(PIVAS) in the third affiliated hospital of Guangzhou Medical College.Methods A total of 2 529 prescriptions of antitumor drugs from PIVAS were analyzed from January to December in 2007.Results It should be paid more attention to some issues during the check of antitumor prescription and mixture of antitumor drugs,including the selection and volume of carrier,the dosage,timing and sequence of medication,and the speed of infusion.Conclusion The advanced technique of PIVAS and checking of pharmacists' can promote the rational application of antitumor drugs.
关键词(KeyWords)：
静脉药物配置中心;抗肿瘤药;合理用药
PIVAS;antitumor drugs;rational application of drugs
基金项目(Foundation):
作者(Author):
黎刚,郑师明,刘颂华,黄永英,陈锡均
LI Gang1,ZHENG Shi-ming1,LIU Song-hua1,HUANG Yong-ying1,CHEN Xi-jun2(1.Department of Pharmacy
参考文献(References)：
- 1沈宜,汤为学,段红,等.顺铂和依托泊苷对人肺癌细胞株PAa、PG的药效动力学.复旦学报(医学版),2003,30(1):56-58.
- 2张晓景.硫普罗宁的药理作用及临床应用.中国药业,2005,14(8):91-92.
- 3 Pujol Mun~oz oz M,Prat J,et al.Stability study of epirubicinin NaCl 0.9%injection.Ann Pharmacother,1997,31(9):992-995.
- 4尹雅姝,陈大为,乔明曦,等.RT-HPLC法测定胸腺五肽溶液的稳定性.沈阳药科大学学报,2007,24(2):89-93.
- 5 Levi F,Focan C,Karaboue A,et al.Implications of circadianclocks for the rhythmic delivery of cancer therapeutics.AdvDrug Deliv Rev,2007,59(9-10):1015-1035.
- 6 Focan C.Pharmaco-economic comparative evaluation ofcombination chronotherapy vs.standard chemotherapy forcolorectalcancer.Chronobiol Int,2002,19(1):289-297.
- 7黎月玲,郑企琨.治疗药物监测实验室全面质量管理的实施.广东药学院学报,2003,19(1):62-64.