今日药学

2021, v.31(12) 954-960

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脂质过氧化诱导铁死亡参与动脉粥样硬化形成机制的研究进展
Research Progress on Mechanisms of Lipid Peroxidation Induced Ferroptosis Involved in Atherosclerosis

刘素连;叶冬宁;丘爱兰;陈杰;许静;
LIU Sulian;YE Dongning;QIU Ailan;CHEN Jie;XU Jing;Preparation Center of Dermatology Hospital of Southern Medical University;School of Pharmacy,Guangzhou Xinhua University;Department of Pharmacy,the First Affiliated Hospital of Sun Yat-sen University;

摘要(Abstract):

铁死亡是一种主要由铁依赖性脂质过氧化介导的调节性细胞死亡方式,在形态、病理生理和机制上不同于细胞凋亡、坏死等其他细胞死亡方式。铁死亡参与动脉粥样硬化、癌症等多种疾病的发生发展。研究发现铁死亡在动脉粥样硬化发展过程起重要作用,其机制可能为各类细胞加重氧化应激导致的铁死亡而引起炎症反应。本文主要对血管内皮细胞、平滑肌细胞以及巨噬细胞铁死亡与动脉粥样硬化之间的产生机制的最新研究进展作一综述,以期为此类疾病的研究和治疗提供新的思路和参考。
Ferroptosis is a type of regulated cell death that is mainly mediated by iron-dependent lipid peroxidation, which is morphologically, physiologically, and mechanistically distinct from apoptosis and necrosis.Ferroptosis has been implicated in the pathophysiological processes associated with atherosclerosis, cancer, and so on.Recent studies have reported that ferroptosis plays an important role in the atherosclerotic lesion, its mechanism may be that ferroptosis is caused by aggravating oxidative stress from various types of cells, which can induce.inflammation in the atherosclerosis This paper mainly summarizes the latest research progress on the mechanism of ferroptosis of vascular endothelial cells, smooth muscle cells, macrophage involved in atherosclerosis, with a focus on providing new targets and references for the research and the treatment of related diseases.

关键词(KeyWords): 铁死亡;动脉粥样硬化;炎症;血管内皮细胞;平滑肌细胞;巨噬细胞
ferroptosis;atherosclerosis;inflammation;endothelial cells;smooth muscle cells;macrophage

Abstract:

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基金项目(Foundation): 广东省自然科学基金项目(2018A030313138);; 广东省医院药学研究基金项目(2020A20)

作者(Author): 刘素连;叶冬宁;丘爱兰;陈杰;许静;
LIU Sulian;YE Dongning;QIU Ailan;CHEN Jie;XU Jing;Preparation Center of Dermatology Hospital of Southern Medical University;School of Pharmacy,Guangzhou Xinhua University;Department of Pharmacy,the First Affiliated Hospital of Sun Yat-sen University;

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