今日药学

2013, v.23(08) 506-508+514

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痫健胶囊的制备及与抗癫痫药联用的临床观察
Preparation of Xianjian Capsule and Effect Observation of Xianjian Capsule Combined with Antiepileptic Drugs

黎伟金;朱庄松;
LI Wei-jin1,ZHU Zhuang-song2(1.Pharmacy Department,the Third People′s Hospital of Meizhou,Meizhou,Guangdong 514089,China; 2.Pharmacy Department,People′s Hospital of Meizhou,Meizhou,Guangdong 514000,China)

摘要(Abstract):

目的研制痫健胶囊,用于治疗各类型癫痫,并观察该药与丙戊酸钠联合应用的临床疗效。方法采用煎煮、浓缩、制粒等制剂工艺制成胶囊剂并与丙戊酸钠联合应用进行临床观察。将380例患者随机分成2组,各190例。对照组给予丙戊酸钠单药治疗,儿童剂量20~30 mg/(kg.d),成人剂量600~1 200 mg/d;治疗组在对照组基础上加服痫健胶囊,1次5粒,1日3次。儿童1次2~3粒,1日3次。2组从开始接受治疗起,连续观察12个月。比较服药前后患者癫痫发作次数,并记录分析药物不良反应。结果临床总有效率对照组为76.8%,治疗组为94.7%;不良反应较轻。治疗组疗效显著优于对照组(P<0.05)。结论痫健胶囊质量可控,与丙戊酸钠联合应用治疗癫痫,比丙戊酸钠单药治疗疗效增强,副作用小,值得推广应用。
Objective To develop Xianjian capsule for the treatment of various types of epilepsy,and observe the efficacy of temporary application of the drug combined with sodium valproate.Methods The capsules were made by boiling,concentrated,and granulation preparation process.The clinical effect of Xianjian capsule combined with sodium valproate was observed.380 patients were randomly divided into 2 groups,190 cases in each group.Patients in the control group were treated by sodium valproate monotherapy,2030 mg/(kg·d) for children,60030 mg/(kg·d) for children,6001 200 mg/d for adult.Patients in Xianjian capsules treatment group were given Xianjian capsules on the basis of the control group,5 once,3 times a day.From the start of treatment,the 2 groups were observed for continuous 12 m.The number of seizures in patients were compared before and after the treatment.The adverse drug reactions were recorded and analyzed.Results The clinical total effective rate was 76.8% in the control group and 94.7% in the treatment group,and with miner adverse reactions.The effect of the treatment group was significantly better than that of the control group(P<0.05).Conclusion The quality of Xianjian capsule can be controlled.Xianjian capsule can enhance the effect of sodium valproate in treatment of epilepsy when the capsule is combined with sodium valproate,with less side effects,and can be widely applied.

关键词(KeyWords): 痫健胶囊;制备;癫痫;疗效观察
Xianjian capsule;preparation;epilepsy;efficacy observation

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作者(Authors): 黎伟金;朱庄松;
LI Wei-jin1,ZHU Zhuang-song2(1.Pharmacy Department,the Third People′s Hospital of Meizhou,Meizhou,Guangdong 514089,China; 2.Pharmacy Department,People′s Hospital of Meizhou,Meizhou,Guangdong 514000,China)

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