甘利欣联合美能治疗慢性乙型肝炎疗效观察
何日东
摘要(Abstract)：
目的探讨甘利欣联合美能治疗慢性乙型肝炎的临床效果。方法治疗组采用甘利欣注射液150 mg加入10%葡萄糖注射液250 m l中静脉滴注,每日1次,同时联用美能注射液120 mg加入10%葡萄糖注射液250 m l中静脉滴注,每日1次,疗程30 d;对照组-1为单用甘利欣注射液150 mg加入10%葡萄糖注射液250 m l中静脉滴注,每日1次,疗程30 d;对照组-2单用美能注射液120 mg加入10%葡萄糖注射液250 m l中静脉滴注,每日1次,疗程30 d。结果治疗组与2对照组相比,肝功能指标ALT、T-B IL及肝纤维化指标HA、Ⅳ.C下降更显著(P<0.05),PTA的恢复有效果更明显(P<0.05);纳差、恶心、腹胀、尿黄等症状恢复更快(P<0.05),无严重不良反应发生。结论甘利欣与美能联合治疗慢性乙型肝炎,能更有效恢复肝功能,改善临床症状,且安全性高。
关键词(KeyWords)：
慢性乙型肝炎;治疗;甘草酸二铵;复方甘草酸苷
基金项目(Foundation):
作者(Author):
何日东
参考文献(References)：
- [1]第十次全国病毒性肝炎与肝病学术会议纪要[J].中华传染病杂志,20,19(1):56.
- [2]M ackenze MA.The influence of glycyrrhetin ic ac id on p las-m a cortisol and cortisone in healthy young volunteers[J].JC lin EndocrinolM etab,1990,70:1 637.
- [3]Teruak i A.Inh ib itory effects of glycyrrhetic ac id deriv ativeson 11β-and 3α-hydroxysteroid dehydrogenases of ratliver[J].Chem Pharm Bu ll,1992,40(11):3 021.
- [4]K imura M,Inoue H,H irabayash i K,et al.G lycyrrh izin andsom e analogues induce growth of prim ary cu ltured adu lt rathepatocytes via ep iderm al growth factor receptors[J].Eur JPharm acol,2001,431:151.
- [5]Schemm er P.Intravenous glyc ine improves survival in ratliver transp lantation[J].Am J Physiol,1999,276:924.
- [6]W heelerMD,Ikejem a,K,Enomoto N,et al.G lyc ine:a newanti-inflamm atory immunonutrient[J].Cell Mol L ife Sc i,1999,56:843.
- [7]K im K,Rh im T,Choi I,et al.N-acetylcyste ine inducescell cyc le arrest in hepatic stellate cells through its reduc ingactivity[J].J B iol Chem,2001,276:40 591.
- [8]宋方闻,李学俊,江元森.复方甘草甜素(SNMC)对肝病理改变观察[J].中国现代医学杂志,2001,11:24.
- [9]Kazuh iko M.E fficacy of Stronger Neo-M inophagen C com-pared between two doses adm in istered three tim es a week onpatients w ith chron ic viral hepatitis[J].J of GastroenterolHepatol,2002,17:1 198.
- [10]Kum ada H.Long-term treatm ent of chron ic hepatitis C w ithglycyrrh izin[stronger neom inophagen C(SNMC)]for pre-venting liver c irrhosis and hepatocellu lar carc inom a[J].Oncology,2002,62(Supp l 1):94.
- [11]刘艳,宋方闻,胡毅文,等.复方甘草甜素治疗慢性乙型肝炎临床疗效观察[J].中国药房,2002,13(7):420.
- [12]曹阳,宋文闻,唐小平.β体甘草酸与α体甘草酸治疗慢性乙型肝炎临床疗效比较[J].中国现代医学杂志,2002,12(7):91.
- [13]W ang BE.Treatm ent of chron ic liver d iseases w ith trad i-tional Ch inese m ed ic ine[J].J Gastroenterol Hepatol,2000,15(Supp l):67.
- [14]于烨,刘玉录,吕爱平.甘草酸的研究进展[J].中华医药杂志,2006,1:11-12.