某三甲医院门诊处方超说明书用药分析Analysis of Off-label Use in Grade-A Tertiary Hospital
陈炎英,程小荣,辛玲,陈社带,刘锐锋
CHEN Yanying,CHENG Xiaorong,XIN Ling,CHEN Shedai,LIU Ruifeng
摘要(Abstract)：
目的调查分析医院门诊处方超说明书用药情况。方法筛选2016年某院门诊处方2 250张,调查并分析本组门诊处方的超说明书用药率、用药类型、涉及科室及用药种类。结果 2 250张门诊处方中共包含7 500条用药记录,其中超说明书用药处方为230张(10.22%),超说明书用药记录为325条(4.33%)。超给药剂量的发生率明显高于超给药频次、超适应证、超年龄、超疗程、超溶媒的发生率,差异有统计学意义(P<0.01)。本组门诊处方超说明书用药的前3位药物种类为甲氨蝶呤片36张(15.65%)、阿司匹林肠溶片24张(10.43%)、泮托拉唑肠溶胶囊23张(10.00%)。结论超说明书用药十分普遍,且具有一定的风险,所以应尽早完善相关规定与制度,保证患者的用药质量。
OBJECTIVE To investigate and analyze the drug use of out-patient prescriptions in the hospital. METHODS 2 250 outpatient prescriptions in our hospital in 2016 were selected,investigated and analyzed the out label drug use rate,drug types,related departments and drug types of outpatient prescriptions. RESULTS The 2 250 outpatient prescriptions in this group included 7 500 records of drug use,of which 230( 10.22%) were used for super instruction.325( 4.33%) cases of super instructions were recorded. The rate of super dose in this group was significantly higher than the frequency of super administration,super adaptation,super age,super course,and the incidence of super solvent( P < 0. 01). The top three drugs for outpatient prescriptions were Methotrexate Tablets( 15.65%),Aspirin Enteric-coated Tablets( 10. 43%),and pantoprazole enteric coated capsules( 10%). CONCLUSION Super instruction is very common and has a certain risk. so,the relevant regulations and systems should be perfected as soon as possible to guarantee the quality of the patients medication.
关键词(KeyWords)：
门诊处方;超说明书用药;调查
out-patient prescriptions;off-label use;investigation
基金项目(Foundation):
作者(Author):
陈炎英,程小荣,辛玲,陈社带,刘锐锋
CHEN Yanying,CHENG Xiaorong,XIN Ling,CHEN Shedai,LIU Ruifeng
参考文献(References)：
- [1]汤丽萍.静脉配置中心药师对医院病区超说明书用药情况分析与干预[J].中国处方药,2018,16(1):41-42.
- [2]陆昊,夏海建,蒋倩,等.某院门诊超说明书用药情况分析.今日药学,2016,26(11):816-818.
- [3]苏芬丽,沈创鹏,麦美琪,等.GLP-1受体激动剂超说明书用药情况调查及合理性分析[J].中国现代应用药学,2017,34(11):1611-1615.
- [4]蔡鸿福,张惠敏,刘茂柏.注射用质子泵抑制剂超说明书用药调查分析[J].中国现代应用药学,2016,33(9):1209-1211.
- [5]崔鸿江,陈佳星,张晓丽,等.某院2014~2016年住院患者活血化瘀类中药注射剂应用分析[J].中国医药导报,2017,14(33):161-164.
- [6]李殿华.医院门诊处方超说明书用药的调查研究及管理对策[J].中国卫生产业,2017,14(33):172-173.
- [7]范健,刘华,吕建峰.某院中药注射剂使用调查分析[J].临床合理用药杂志,2017,10(32):89-90.
- [8]李亚昙,魏洁群,刘军,等.某三甲医院超说明书用药问卷调查分析[J].中国医院药学杂志,2017,37(23):2391-2395.
- [9]林武斌,陈瑶,杨剑辉.某三甲妇儿医院2016年来曲唑门诊超说明书用药回顾性调查分析[J].中国医院药学杂志,2017,37(24):2486-2489.
- [10]蔡逸虎,张菊.静脉药物配置中心药师对医院病区超说明书用药情况的调查与干预[J].世界最新医学信息文摘,2017,17(90):121-122.
- [11]费霏.医院儿内科住院患儿超说明书用药情况分析[J].中国医刊,2017,52(11):96-99.
- [12]陈昭阳,苏娜,朱阳慧,等.某三甲医院呼吸内科门诊处方中超药品说明书用药情况分析[J].中国医院药学杂志,2017,37(22):2300-2303.
- [13]陈瑶,杨剑辉,林武斌,等.某三甲妇儿医院门诊超说明书用药调查分析[J].中国临床药学杂志,2017,26(5):315-319.
- [14]吴万初.门诊超说明书用药情况调查与管理优化[J].海峡预防医学杂志,2017,23(4):90-92.
- [15]彭志凤.门诊静脉药物超说明书用药调查分析[J].北方药学,2016,13(8):178.
- [16]韩毅音,徐蓓,梅升辉,等.中国医院超说明书用药调查与对策研究[J].中国临床药理学杂志,2016,32(8):756-758.
- [17]崔学艳,时银萍,时海燕,等.超说明书用药管理及药学服务模式探讨[J].中国医院药学杂志,2016,36(9):751-754.
- [18]朱安祥,汪涛.超说明书用药的风险及其防范[J].中国医院用药评价与分析,2016,16(1):126-128.
- [19]张镭,谭玲,王少华,等.国内24家医疗机构超说明书用药现状调查与分析[J].中国药学杂志,2016,51(2):151-154.
- [20]邓志威,杨雪英,郑锦坤.基层医院超说明书用药行为的评价与干预[J].今日药学,2015,25(4):283-286.