一例高血压合并高尿酸患者的药学监护Pharmadceutical Care for A Patient with Hypertension and Hyperuricemia
徐象威,李如雅,吕向群
XU Xiangwei,LI Ruya,LV Xiangqun
摘要(Abstract):
目的探讨临床药师在内分泌科开展药学服务的方法和思路。方法对临床药师在内分泌科参与的1例高血压合并高尿酸住院患者的药学监护过程进行分析总结。结果临床药师通过药物相互作用、药物不良反应和患者用药教育等方面,积极配合临床医师,优化药物治疗方案,提高了患者用药依从性,保障患者用药的安全性。结论临床药师参与临床药学实践,可提高患者用药安全性和有效性。
OBJECTIVE To discuss the clinical pharmacist 's role on pharmaceutical care in endocrinology department.METHODS The clinical pharmacist's effect on pharmaceutical care to a patient with hypertension and hyperuricemia was analyzed and summarized. RESULTS The clinical pharmacist cooperated with the clinical physicians actively through drug interactions and adverse drug reactions and patient education,to optimize the drug treatment and increase patient compliance and enhance the safety of drug application. CONCLUSION Clinical pharmacist can improve the safety and efficacy of patient's medication by participating climical therapeutic practice.
关键词(KeyWords):
临床药师;高血压;高尿酸血症;药学监护
clinical pharmacist;pharmaceutical care;hyperuricemia;hypertension
基金项目(Foundation):
作者(Author):
徐象威,李如雅,吕向群
XU Xiangwei,LI Ruya,LV Xiangqun
参考文献(References):
- [1]Nakagawa T,Hu H,Zharikov S,et al.A causal role for uric acid in fructose2 induced metabolic syndrome[J].Am J Physiol,2006,2909(3):F625-631.
- [2]Yu MA,Sánchez-Lozada LG,Johnson RJ,et al.Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction[J].J Hypertens,2010,28(6):1234-42.
- [3]Perticone F,Maio R,Tassone JE,et al.Interaction between uric acid and endothelial dysfunction predicts new onset of diabetes in hypertensive patients[J].Int J Cardiol,2013,167(1):232-236.
- [4]中国高血压防治指南修订委员会,2010高血压防治指南[J].中国医学前沿杂志,2011,3(5):42-85
- [5]中华医学会内分泌学分会,高尿酸血症和痛风治疗的中国专家共识[J].中国内分泌代谢杂志,2013.29(11):913-920.
- [6]杨素敏,何权瀛,苗懿德.血管紧张素转化酶抑制剂所致咳嗽与血管紧张素转化酶基因型相关性的研究[J].中华结核和呼吸杂志,2003,26(4):203-205.
- [7]Rayner BL,Trinder YA,Baines D,et al.Effect of losartan versus candesartan on uric acid Renal function,and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics[J].Am J Hypertens,2006,19(2):208-213.
- [8]朱慧.氯沙坦钾应用于社区高血压合并高尿酸血症患者治疗的效果探讨[J].基层医学论坛,2015,(11).
- [9]姚喜芳.氯沙坦对原发性高血压合并高尿酸血症患者血压及血尿酸水平的影响[J].中国老年保健医学,2014,2(3).
- [10]Leu I G,Huang CM,Kao SJ,et al.Efifcacy and safety of losartanin patients with proteinuria[J].Nephron,2002,91(3):496-498.
- [11]张金春.缬沙坦治疗原发性高血压伴高尿酸血症的临床观察[J].中国医药科学,2015,5(4):52-53.
- [12]肖立中,江志平,黄志,等.别嘌呤醇对冠心病患者内皮功能及心功能的影响[J].中国循环杂志,2003,18(1):16.
- [13]沈赟,金星,陶沙,等.不同剂量非布司他与别嘌呤醇对高尿酸血症伴痛风患者可溶性细胞间黏附分子1影响的对比观察[J].中国全科医学,2014,17(14):1665-1667.