郭洁文,廖惠芳,潘竞锵,叶碧波,廖雪珍,谢婉君,肖柳英,韩超
GUO Jie-wen; LIAO Hui-fang 1; PAN Jing-qiang 2;YE Bi-Bo 3; ZLIAO Xie-zhen 2;XIE Wan-jun; XIAO Liu-ying 2; HAN Chao 2 (Guangzhou Hospital of Traditional Chinese Medicine Guangzhou;

• 1:广州市中医医院
• 2:广州中医药大学
• 3:广州市中医中药研究所
• 4:广东省药物研究所

摘要(Abstract)：

目的　研究荔枝核皂苷对地塞米松 (DX)致胰岛素抵抗 (insulinresistance,IR)大鼠血糖、血脂的影响。方法　采用DX诱导IR大鼠模型 ,观察荔枝核皂苷和罗格列酮对病鼠空腹血糖 (FBG)和口服葡萄糖耐量试验 (OGTT)后 2h血糖 (2hBG)以及给药后 2h空腹血清血糖 (FSG)、总胆固醇 (TC)、三酰甘油 (TG)、高密度脂蛋白 -胆固醇 (HDL -C)、低密度脂蛋白 -胆固醇(LDL -C)、丙二醛 (MDA) ,以及丙氨酸氨基转移酶 (ALT)、天冬氨酸氨基转移酶 (AST)、超氧化物歧化酶 (SOD)活性等指标的影响。结果　荔枝核皂苷改善DX致IR模型大鼠的IGT ,降低OGTT后 2h期BG和FSG(P <0 .0 5 ) ;并能显著降低病鼠TC、TG、LDL -C含量 (P <0 .0 5 - 0 .0 1) ,显著提高HDL -C含量 (P <0 .0 5 ) ;抑制AST、ALT活性 (P <0 .0 5 ) ,降低AST/ALT ;加强SOD活性和降低MDA的含量 (P <0 .0 1) ,增强抗氧化能力。结论　荔枝核皂苷对DX致IR大鼠有降血糖、调血脂改善肝功能等的作用 ,显示抗氧化作用
Objective To investigate the effects of saponin of litchi seed on blood glucose, blood lipid in dexamethasone (DX) -induced insulin resistant rats. Methods With DX-induced insulin resistant rats, to observed roglitazone and saponin of Litchi, intragastroesophageally administered,qd×8d,on fasting blood glucose (FBG), 2-hours blood glucose (2hBG) after oral glucose tolerance test (OGTT),serum contents of fasting glucose ( FSG ), malondialdehyde (MDA),total cholesterols (TC), triacylglycerol (TG),high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and activities of superoxide dismutase (SOD), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and their ratio (AST/ALT) .Results The saponin of litchi seed lowered FBG (P<0.05) and 2hBG (P<0.05) after OGTT, improved IGT, lowered FSG(P<0.05); reduced the content of MDA, TC, TG, LDL-C and activity of AST,ALT,and the ratio (AST/ALT) (P<0 05), but roglitazone didn’t reduce the activities of AST, ALT, the ratio (AST/ALT)(P>0.05); both of them increased the content of HDL-C and improved activity of SOD (P<0.05～0.01). Conclusions The results suggest that the effects of saponin of litchi seed,which are lowering blood glucose, and lipid improving function of liver regulating components and contents of blood lipid,and potentiating antioxidation are proved in DX-induced insulin resistant rats.

关键词(KeyWords)： 荔枝核皂苷;罗格列酮;地塞米松;胰岛素抵抗;血糖;血脂
saponin of litchi seed; roglitazone;dexamethasone;insulin resistance; blood glucose;blood lipid

Abstract:

Keywords:

基金项目(Foundation): 广东省中医药局滚动资助项目 (30 2 0 0 2 );; 广州市中医药、中西医结合资助项目 (2 0 0 2 14 )

作者(Authors): 郭洁文,廖惠芳,潘竞锵,叶碧波,廖雪珍,谢婉君,肖柳英,韩超
GUO Jie-wen; LIAO Hui-fang 1; PAN Jing-qiang 2;YE Bi-Bo 3; ZLIAO Xie-zhen 2;XIE Wan-jun; XIAO Liu-ying 2; HAN Chao 2 (Guangzhou Hospital of Traditional Chinese Medicine Guangzhou;

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