杜艳平,朱惠莲
DU Yan-ping ZHU Hui-lian(Epartment of Nutrition,School of public health

• 1:中山大学公共卫生学院营养学系
• 2:中山大学公共卫生学院营养学系 广州510080
• 3:广州510080

摘要(Abstract)：

黄曲霉毒素B1(AFB1)的长期暴露是肝癌发生的主要危险因素之一,研究发现它可能通过影响ras、c-fos、P53、Survivin等基因的表达而引起肝癌的发生,此外,它还与其它肝癌的高危因素,如乙肝病毒(HBV)的慢性感染等协同作用而促进肝癌的发生和发展。HBx基因的整合及AFB1的攻击可能通过影响DNA修复系统、药物代谢酶系统及细胞色素P450(CYP)代谢酶基因的异常表达导致肝癌的发生。植物化学物,如叶绿酸、茶多酚、茶色素、姜黄素、黄酮类化合物等或/和其含量较高的食物在预防肝癌发生和发展中起重要的作用。本文对AFB1致肝癌的机制及植物化学物防治作用的研究进展作一综述。
Long-term exposure to Aflatoxin B_1(AFB_1) is one of major risk factors in hepatocarcinogenesis.Some researches suggested that AFB_1 may induce hepatocarcinogenesis by influencing some genes expression,including ras,c-fos,P53 and Survivin.The synergistic interaction of AFB_1 and HBV promotes hepatocarcinogenesis.The integration of HBx gene and the attack of AFB_1 may induce hepatoma by influencing the system of DNA repair,the system of drug-metabolizing enzymes and the expression of cytochrome P450(CYP) genes.Phytochemicals,such as chlorophyllin,tea polyphenols,tea-pigment,curcumine,flavonoids and the foods rich in these phytochemicals can play important roles in prevention of hepatocarcinogenesis.This review is concentrating on the mechanism of hepatocarcinogenesis and the preventive effects of phytochemicals.

关键词(KeyWords)： 黄曲霉毒素B1;肝癌;乙肝病毒;植物化学物
aflatoxin B_1(AFB_1);hepatoma;hepatitis B virus(HBV);phytochemicals

Abstract:

Keywords:

基金项目(Foundation): 广东省自然科学基金资助项目(31676)

作者(Author): 杜艳平,朱惠莲
DU Yan-ping ZHU Hui-lian(Epartment of Nutrition,School of public health

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