今日药学

2020, v.30(06) 419-422

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苦豆子片联合HAART治疗艾滋病患者临床研究
Clinical Study of Sophoraalopecuroides Tablets Combined with HAART in the Treatment of AIDS Patients

傅晓霞;毛慧君;徐惠琼;肖文剑;
FU Xiaoxia;MAO Huijun;XU Huiqiong;XIAO Wenjian;Department of Traditional Chinese Medicine,Guangzhou Eighth People's Hospital;Department of Anatomy,Guangdong Medical University;

摘要(Abstract):

目的探讨苦豆子片联合高效抗逆转录病毒疗法(highly active antiretroviral therapy,HAART)对艾滋病患者的疗效以及外周血CD4~+、CD8~+,CD45~+淋巴细胞计数的影响。方法选取艾滋病患者112例,采用随机数表法将患者分为对照组和治疗组各56例。对照组采用HAART疗法,治疗组予HAART联合口服苦豆子片,0.25 g×3片,tid,疗程6个月。评估治疗前、治疗3、6个月后临床症状体征总积分及卡洛夫斯基积分(Karnovsky Score);检测血CD4~+、CD8~+和CD45~+淋巴细胞计数的表达。结果治疗后,两组各时点的临床症状体征总积分和卡洛夫斯基积分均较治疗前改善(P<0.05),同时间点的组间比较,治疗组优于对照组(P<0.05);治疗后,外周血CD4~+,CD8~+和CD45~+淋巴细胞计数,同组三者均较治疗前改善(P<0.05);组间分别比较,治疗组优于对照组(P<0.05)。外周血HIV-1病毒载量,同时点同组治疗前后比较,差异有统计学意义(P<0.05);治疗后同时点组间比较,差异无统计学意义(P>0.05)。结论苦豆子片联合HARRT治疗艾滋病患者,临床疗效显著,值得临床推广。
OBJECTIVE To investigate the effect of Sophoraalopecuroides tablet combined with highly active antiretroviral therapy( HAART) on AIDS patients and the lymphocytes counts of CD4~+,CD8~+,CD45~+in peripheral blood. METHODS 112 AIDS patients were randomly divided into the control group and the treatment group with 56 cases in each group. The control group was treated with HAART,and the treatment group was administrated with Kudouzi tablet( 0.25 g×3 tablets per time,three times a day) on the basics of HAART. The overall scores of signs and symptoms as well as the Karnovsky scores were evaluated in all patients at 0,3,and 6 months after treatment,respectively,accompanied by monitoring the T-lymphocyte counts of CD4~+,CD8~+ and CD45~+. RESULTS The treatment effectively improved the total score of clinical symptoms and the score of karnovsky in the both groups at each time point( P<0.05).At the same time point,the treatment group was better than that in the control group( P< 0.05). After the treatment,the T-lymphocyte counts of CD4~+,CD8~+ and CD45~+were increased significantly in the both groups( P < 0. 05). There was significant difference between the both groups at each time point(P < 0. 05),The viral load of the treatment group and the control group were reduced after the treatment( P < 0. 05),but there was no statistically significant difference between the both groups at each time point( P>0.05). CONCLUSION The clinical effect of Kudouzi tablets combined with HARRT in the treatment of AIDS patients is significant and the treatment method is worthy to be promoted.

关键词(KeyWords): 苦豆子片;艾滋病;T淋巴细胞;高效抗逆转录病毒疗法
sophoraalopecuroides tablets;AIDS;T cells;HAART

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基金项目(Foundation): 广东省中医药局科研立项资助项目(20201271)

作者(Author): 傅晓霞;毛慧君;徐惠琼;肖文剑;
FU Xiaoxia;MAO Huijun;XU Huiqiong;XIAO Wenjian;Department of Traditional Chinese Medicine,Guangzhou Eighth People's Hospital;Department of Anatomy,Guangdong Medical University;

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