氧氟沙星、环丙沙星抗胆道感染作用的实验研究The experimental research on the anti-infection of biliary tract with ofloxacin and ciprofloxacin
孙桂华,赵树进,黄小让
Sun Gulhua;Zhao Shujing;Huang Xiaorang(Guangzhou Military General Hospital 510010);
摘要(Abstract)：
目的 :观察喹诺酮类抗生素 (环丙沙星、氧氟沙星 )在胆汁中的代谢过程 ,为临床医师提供胆道感染时合理选用有效抗生素的理论依据。方法 :犬为实验动物 ,行胆总管造瘘 ,以备留取胆汁标本。静脉滴注氧氟沙星 (Ofloxacin)、环丙沙星 (Ciprofloxacin)后 ,留取静脉及胆汁标本 ,用微生物法测定药物浓度 ,3P87软件数据处理 ,得出药物动力学参数。结果 :静脉滴注氧氟沙星、环丙沙星后 ,胆汁中主要的代谢参数 :峰值时间 (Tpeakmin)分别为 58、 72 ;峰值浓度 (Cmaxμg/ml)分别为 8.0 2、 8.81;半衰期 (T1/2 h)分别为 7.66、 8.2 3;清除率 (CLml/min)分别为 30 .35、 2 6.7。结论 :静脉滴注氧氟沙星及环丙沙星后 ,二者在胆汁中浓度较高 ,半衰期长 ,是治疗胆道感染较为理想的抗生素之一
Objective:To observe the metabolic process of 4-quinoles antibiotic and provide the theoretic basis for physician selecting effective antibiotic rationally when biliary tract is infected.Mothods:Dog experiment:Carry out choledochostomy in order to reserve samples of bile.After injecting ofloxacin or ciprofloxacin,reserve samples of bile and vein blood,detect drug density with microbiological method,process data with 3P87 statistical software and obtain pharmacokinetics parameters.Results :After injecting ofloxacin or ciprofloxacin through vein,the main metabolic parameters about bile:Tpeak(min)was 58.72;Cmax(μg/ml)were 8.02,8.81;T 1/2 (h)were 7.66,8.23;CL(ml/min) were 30.35,26.70. Conclusion: After injected through vein,the density of ofloxacin or ciprofloxacin in bile was high and their half life time was long comparatively. The results suggested that ofloxacin or ciprofloxacin would be one of the better antibiotic for treating biliary tract infection.
关键词(KeyWords)：
氧氟沙星;环丙沙星;胆汁;药代动力学
Ofloxacin, Ciprofloxacin,Bile,Pharmacokinetics
基金项目(Foundation):
作者(Authors):
孙桂华,赵树进,黄小让
Sun Gulhua;Zhao Shujing;Huang Xiaorang(Guangzhou Military General Hospital 510010);