姚晖,邓虹珠,张继平,易延逵,潘球正
YAO Hui1,DENG Hong-zhu2,ZHANG Ji-ping1,YI Yan-kui2,PAN Qiu-zheng2 (1.The Pharmacy Department of the Second People's Hospital of Foshan

• 1:佛山市第二人民医院药剂科
• 2:南方医科大学中医药学院

摘要(Abstract)：

目的研究银杏内酯缓释片的制备方法,筛选出最佳制备工艺条件。方法采用四因素(甲壳素、柠檬酸、乳糖、卡波姆用量)三水平正交实验设计,以释放度综合评分为评价指标,确定银杏内酯缓释片的最佳制备工艺条件;并对优化的试验结果考察其体外释放效果。结果最佳工艺条件甲壳素、柠檬酸、乳糖、Carbomer用量分别为15、1、6、20mg,所制备的银杏内酯缓释片在1、2、4、6、12h的体外累积释放率分别为27.10%、40.15%、49.23%、57.47%、82.25%。结论制备的银杏内酯缓释片缓释效果良好,制备工艺简单易行,累积释放率符合要求。
Objective To investigate the preparation method of Ginkgolides sustained release tablets,so as to optimize the preparation technology conditions for these preparations.Methods The preparation technology conditions were optimized by orthogonal design with the amounts of chitin,citric acid,lactose,carbomer,with the release rate of Ginkgolides sustained release tablets as indexes.The optimized results were verified,and the in vitro release of Ginkgolides sustained release tablets was determined.Results The optimum preparation technology conditions of Ginkgolides sustained release tablets were as follows:the amounts of chitin,citric acid,lactose,and carbomer were 15,1,6,and 20 mg,respectively; and the in vitro release rates at 1,2,4,6,and 12 h were 27.10%,40.15%,49.23%,57.47%,and 82.25%,respectively.Conclusion The delayed release effect of Ginkgolides sustained release tablets is better.The preparation is easy.The in vitro accumulated drug release is in conformity with the requirements.

关键词(KeyWords)： 银杏内酯;缓释片;释放度
Ginkgolides; sustained release tablets; release rate

Abstract:

Keywords:

基金项目(Foundation): 2005年度佛山市科技发展专项基金资助项目(编号:200508064)

作者(Author): 姚晖,邓虹珠,张继平,易延逵,潘球正
YAO Hui1,DENG Hong-zhu2,ZHANG Ji-ping1,YI Yan-kui2,PAN Qiu-zheng2 (1.The Pharmacy Department of the Second People's Hospital of Foshan

参考文献(References)：

• 1邵继平,王伯初,陈欣,等.银杏叶提取物药用价值的研究进展.重庆大学学报,2003,26(1):130-134.
• 2张国宏,荆树汉,潘丽春,等.银杏叶缓释片的工艺探讨.广西医学,2006,28(5):643-645.
• 3程志青.南雄银杏叶中银杏内酯的高效液相色谱法测定.分析测试学报,2002,21(4):17-18.
• 4吴闯,肖学成.克拉霉素缓释片释放度研究.中国药房,2004,15(4):238-240.
• 5曾雪芳,李卫中.口服缓控释制剂的研究进展.今日药学,2008,18(2):20-22.
• 6赵瑞芝,王中彦,胡良才.新型缓释片剂辅料甲壳胺的研究.天然产物研究与开发,1997,9(4):68-71.
• 7Nigalaye AG.Adusumili P.Investigation of prolonged drug release from matrix formulations of chitosan J.Drug Dev Ind Pharm,1990,16(3):449-467.