今日药学

2019, v.29(12) 835-839

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

某院门诊rhGM-CSF药物超说明书使用情况分析
Analysis of Off-label Drug Use of rhGM-CSF in Outpatient Department of A Hospital

胡继藤;刘澍;周捷;刘韬;黄红兵;刘庆;
HU Jiteng;LIU Shu;ZHOU Jie;LIU Tao;HUANG Hongbing;LIU Qing;State Key Laboratory of Oncology in South China/Collaborative Innovation Center for Cancer Medicine/Sun Yat-sen University Cancer Center;

摘要(Abstract):

目的调查分析某院门诊处方中重组人粒细胞巨噬细胞刺激因子(rhGM-CSF)的超说明书用药情况。方法通过HIS抽取2016年6月~2018年6月该院开具的含rhGM-CSF的处方,以rhGM-CSF药品说明书为依据,调查并分析其超说明书用药率、涉及科室、用药类型。通过中国知网和Pubmed数据检索中外文献,查找超说明书用药的临床依据和用药指南,进而分析讨论rhGM-CSF超说明书用药的规范性和合理性。结果共抽取到含rhGM-CSF的处方692张,其中超说明书用药处方381张(55.06%),超说明书用药频次580次。主要分布于鼻咽癌科(37.59%)、内科(24.14%)、儿童肿瘤科(13.10%)等。超说明用药类型分为超途径给药(26.90%)、超给药频次(25.17%)、超给药周期(23.10%)、超给药年龄(23.10%)和超说明使用溶媒(1.72%)5类。将rhGM-CS配制成漱口液用于治疗鼻咽癌放化疗后的口腔粘膜损伤是该院门诊最常见的超说明书用药方式。结论 rhGM-CSF药物的超说明书用药情况普遍存在,其合理性和科学性大多有文献支持,但也存在部分不合理用药情况,应尽快完善药品说明书,加强监管,保障患者用药安全。
OBJECTIVE To analyze the off-label drug use of rhGM-CSF in outpatient department in a hospital. METHODS Prescriptions containing rhGM-CSF were screened through consulting HIS medical management system and patient condition panoramic window system in the hospital from June 2016 to June 2018.Their drug use rate,departments involved and types of drug use were investigated and analyzed base on the drug instruction of rhGM-CSF.The clinical basis and medication guide for the use of rhGM-CSF was found out by searching Chinese and foreign literature through CNKI and Pubmed database.Then the standardization and rationality of rhGM-CSF medication beyond the instruction was discussed. RESULTS 692 prescriptions including rhGM-CSF were prescribed,in which 381 prescriptions(55.06%) were off-label drug use with 580 times.The top three department was the department of Nasopharynx(37.59%) and Internal medicine(24.14%) and Pediatric Oncology(13.10%).Five types of off-label drug use were as follows:over routes of administration(26.90%),over medication frequency(25.17%),over medication cycles(23.10%),over medication age(23.10%) and over medication solvent(1.72%).Mouthwash prepared by rhGM-CSF to treat Oral mucosal lesions after radiotherapy and chemotherapy of nasopharyngeal carcinoma was the most common way of off-label drug use in the outpatient department of the hospital. CONCLUSION Off-label drug use of rhGM-CSF was very common in our clinic in which most of its rationality and scientificity was most supported by literature.But there is still some unreasonable use of drugs.It is necessary to improve the instruction and strengthen the supervision as soon as possible to ensure the safety of patients' medication.

关键词(KeyWords): 重组人粒细胞巨噬细胞刺激因子;门诊处方;超说明书用药
rhGM-CSF;outpatient prescription;off-label drug use

Abstract:

Keywords:

基金项目(Foundation): 广东省医院药学研究基金项目(2019A16)

作者(Author): 胡继藤;刘澍;周捷;刘韬;黄红兵;刘庆;
HU Jiteng;LIU Shu;ZHOU Jie;LIU Tao;HUANG Hongbing;LIU Qing;State Key Laboratory of Oncology in South China/Collaborative Innovation Center for Cancer Medicine/Sun Yat-sen University Cancer Center;

Email:

DOI:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享