今日药学

2021, v.31(06) 401-404

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兴奋性谷氨酸转运蛋白2作为抑郁治疗靶点的研究进展
Research Progress on Excitatory Glutamate Transporter 2 as a Target for Treatment of Depression

曾婕;洪浩;
ZENG Jie;HONG Hao;Department of Pharmacology, School of Pharmacy, China Pharmaceutical University;

摘要(Abstract):

抑郁症是一种常见精神性疾病,其主要特征是持续的情绪低落和快感缺失。现有的药物存在起效慢、有效率低、副作用大等诸多不足,因此探索抑郁症的发病机制、研究新的治疗靶点具有重要意义。越来越多证据显示,兴奋性谷氨酸转运蛋白2(excitatory amino acid transporter 2,EAAT2)在抑郁症神经递质传递与突触可塑性变化发挥着非常关键的作用。本文将围绕EAAT2在抑郁中的作用及相关药物的研究现状进行综述,阐述EAAT2在抗抑郁药物研究中的意义。
Depression is a chronic mental illness characterized by a persistent low mood and anhedonia. The existing drugs have many deficiencies, such as slow onset, low efficiency and large side effects, so it is of great significance to explore the pathogenesis of depression and find new therapeutic targets. There is growing evidence that excitatory glutamate transporter 2(EAAT2) plays a critical role in neurotransmitter transmission and synaptic plasticity in depression. This review will focus on the role of EAAT2 in depression and the current status of research on related drugs, elaborating the significance of EAAT2 in antidepressant drug research.

关键词(KeyWords): 兴奋性谷氨酸转运蛋白2;抑郁症;谷氨酸
excitatory glutamate transporter 2;depression;glutamate

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基金项目(Foundation): 国家自然科学基金资助项目(81773714)

作者(Author): 曾婕;洪浩;
ZENG Jie;HONG Hao;Department of Pharmacology, School of Pharmacy, China Pharmaceutical University;

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