84例中药注射液不良反应及相关因素分析Analysis of adverse reactions and their related factors in 84 parental herbal solutions
郑彦云,陆平平,吴志红,郑晓菁
Zheng Yanyun; Lu Pingping; Wu Zhihong; Zheng Xiaoqing (Guangdong Center for Adverse Drug Reactions of Monitoring;
摘要(Abstract)：
目的 调查中药注射液引起的不良反应的发生率及临床表现 ,了解中药引起药物不良反应的发生情况。旨在关注用药安全。方法 对 84例中药注射液引起的不良反应进行分析。结果 84例中药注射液不良反应涉及中药品种有 19种。药物不良反应按系统分 ,其中变态反应占 84.52 %。所有不良反应均由静脉给药引起。结论 临床上广泛使用的中药注射液很可能引起不良反应 ,应加强对中药注射液不良反应的监测
Objective To investigate the incidence and manifestation of the adverse reactions of paren tal herbal solutions for better surveillance and safer use of traditional Chines e herbal medicines. Methods The adverse reactions of 84 parenta l herbal solution preparations were reviewed. Results The adve rse drug reactions of 84 parental herbal solution preparations were related to 1 8 traditional Chinese herbal medicines. Hypersensitivity accounted for 84.52% of all adverse reactions, which were all caused by parental administration. Conclusions Adverse drug reactions can be caused by the widely used parental herbal solution preparations. Close surveillance of these preparations for adverse reactions is warranted.
关键词(KeyWords)：
中药;药物不良反应;监测
traditional Chinese herbal medicine;adverse drug reaction; surveillance
基金项目(Foundation):
作者(Authors):
郑彦云,陆平平,吴志红,郑晓菁
Zheng Yanyun; Lu Pingping; Wu Zhihong; Zheng Xiaoqing (Guangdong Center for Adverse Drug Reactions of Monitoring;
参考文献(References)：
- [1]徐 峰,关 英,郑彦云.我院42例中药注射液不良反应报告分析[J].中药材,2003,26(7).
- [2]高东宸.药物不良反应监察指南[M].北京:中国医药科技出版社,1996.
- [3]国家药品不良反应监测中心.药品不良反应知识100问[M ].北京:化学工业出版社,2002.
- [4]郭曙刚.中药注射剂如何安全走向明天[N].医药经济报,2003(05),23,第2版.
- [5]赵新先.中药注射剂学[M ].广州:广东科技出版社,2000.233.
- [6]和培红,陈 超,王艳红,等.中药制剂所致药物不良反应分析[J].中国新药杂志,2003,12(3):217～218.
- [7]ZhuYP .ToxicityoftheChineseherbmutong(Aristolochiamanshuriensis)[J].AdverseDrugReactToxicol,2002,21(4):171～177.
- [8]常 静,朱兴彦,贺 芳.重新审视中药不良反应[J].中华医学信息导报,2002,(24):5～6.