王富海,谭月英,张栋武
WANG Fuhai,TAN Yueying,ZHANG Dongwu

• 1:广东省佛山市高明区妇幼保健院药剂科

摘要(Abstract)：

目的探讨高压氧疗配合地屈孕酮治疗先兆流产的可行性及疗效机制。方法选取本院收治的160例先兆流产患者为研究对象,行随机数字表法划分为观察组(90例)和对照组(70例),前者予高压氧、地屈孕酮配合常规方案治疗;后者仅予地屈孕酮配合常规方案治疗。统计疗效;随访至妊娠结局,统计围生儿结局;持续统计患者治疗前后血清IL-8、TNF-α水平。结果观察组总有效率明显高于对照组(P<0.05);观察组出现难免流产2例,无死胎,对照组出现7例难免流产、1例死胎,2组活产儿率差异显著(P<0.05),其他围生儿结局指标无统计学差异;2组治疗前血清IL-8及TNF-α水平无明显差异,治疗结束后均有明显下降,且观察组水平明显低于对照组,上述差异均有统计学意义(P<0.05)。结论高压氧配合药物治疗先兆流产效果确切,其疗效机制可能与抑制血清IL-8及TNF-α有关。
OBJECTIVE To investigate the feasibility of applying hyperbaric oxygen therapy combined with dydrogesterone in women with threatened abortion and its mechanism of action. METHODS A total of 160 women with threatened abortion in the hospital were selected as the research objects,and they were randomly divided into observation group( 90 cases) and control group( 70 cases).The observation group received hyperbaric oxygen,dydrogesterone combined with conventional therapy. The control group was only given dydrogesterone combined with conventional therapy. The treatment effect were recorded,and followed-up to the outcome of pregnancy and recorded the perinatal outcomes. The levels of serum IL-8 and TNF-α before and after the treatment were also tested. RESULTS The total effective rate of patients in the observation group was obviously higher than that in the control group( P<0.05). There were 2 cases of inevitable abortion in the observation group,while there were 7 cases of inevitable abortion and 1 cases of stillbirth in the control group.The live births rates of the 2 groups differed significantly( P<0.05). But there were no other statistical difference in the perinatal outcome indexes. The serum IL-8 and TNF- levels showed no significant difference between the 2 groups before treatment. After treatment,they were significantly decreased,and the level of the observation group was significantly lower than that of the control group,the difference was statistically significant( P<0.05). CONCLUSION Hyperbaric oxygen combined with medicine in treatment of threatened abortion showed great effect,its therapeutic mechanism may be related to the inhibition of serum IL-8 and TNF-alpha.

关键词(KeyWords)： 先兆流产;保胎;高压氧;白细胞介素8;肿瘤坏死因子α
threatened abortion;tocolysis;hyperbaric oxygen;interleukin 8;tumor necrosis factor alpha

Abstract:

Keywords:

基金项目(Foundation): 2014年度佛山市医学类科技攻关项目(2014AB001134)

作者(Author): 王富海,谭月英,张栋武
WANG Fuhai,TAN Yueying,ZHANG Dongwu

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