王蔚
WANG Wei

• 1:佛山市第一人民医院心内科

摘要(Abstract)：

目的探讨苯磺酸左旋氨氯地平对原发性高血压患者血清脂联素(APN)及颈动脉内膜中层厚度(IMT)的影响。方法选取80例初诊为原发性高血压的患者,给予苯磺酸左旋氨氯地平治疗,采用双抗体夹心酶联免疫吸附法测定所有患者治疗前及治疗后6个月APN水平,并行颈动脉超声检查测量颈动脉IMT。结果治疗前相比,治疗6个月后血清APN明显升高,差异有统计学意义(P<0.01),颈动脉IMT较治疗前降低,差异有统计学意义(P<0.05)。结论清APN的检测对高血压的预后估计有临床意义,苯磺酸左旋氨氯地平可提高原发性高血压患者血清APN浓度,可以延缓颈动脉粥样硬化进程。
OBJECTIVE To investigate the effects of acid levamlodipine on the serum of adiponectin( APN) and carotid artery intima-media thickness( IMT) of hypertensive patients. METHODS A total of 80 patients with essential hypertension were treated by acid Levamlodipine. The level of APN and IMT were measured before treatment and after 6 months treatment. RESULTS Compared with that of before treatment,the serum of APN were significantly higher after 6 months treatment. The difference was statistically significant( P < 0. 01),IMT decreased significantly( P < 0. 05). CONCLUSION Serum of APN detection for hypertensive patients is very important. Acid levamlodipine may increase the serum of APN in patients of essential hypertension,and it can delay the process of carotid atherosclerosis.

关键词(KeyWords)： 原发性高血压;苯磺酸左旋氨氯地平;脂联素;颈动脉内膜中层厚度
essential hypertension;acid levamlodipine;adiponectin;carotid artery intima-media thickness

Abstract:

Keywords:

基金项目(Foundation): 广东省药学会研究基金(2013X36)

作者(Author): 王蔚
WANG Wei

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