今日药学

2015, v.25(07) 513-516

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Archive) | 高级检索(Advanced Search)

沙格列汀对糖尿病合并非酒精性脂肪肝的疗效观察
Efficacy of Saxagliptin in Type 2 Diabetes with Non-Alcoholic Fatty Liver

卢筱华,梁健萍,卢春婷,冯烈
LU Xiaohua,LIANG Jianping,LU Chunting,FENG Lie

摘要(Abstract):

目的观察沙格列汀对初发2型糖尿病合并非酒精性脂肪肝(NAFLD)的临床疗效。方法 34例初发2型糖尿病合并NAFLD的患者分为对照组(n=10)、治疗组(n=11)、联合治疗组(n=13)。对照组给予二甲双胍1.5~2.0 g/d,治疗组给予沙格列汀5 mg/d,联合治疗组给予沙格列汀5 mg/d和二甲双胍1.5~2.0 g/d。所有患者均在治疗前和治疗6月后分别检测体重指数(BMI)、血糖(空腹及早餐后2 h血糖)、糖化血红蛋白(Hb A1c)、空腹胰岛素、血脂(TG、TC、LDL-C)、肝功能(ALT、AST、GGT)、氧化应激指标(尿8-异前列腺素F2α)、肝脏彩超,并计算胰岛素抵抗指数(HOMA-IR)。结果治疗组和联合治疗组在治疗后BMI、血糖、Hb A1c、血脂、肝功能、HOMA-IR、尿8-异前列腺素F2α均有明显改善;与对照组相比,联合治疗组降糖、降脂作用优于对照组,其余指标3组间无统计学差异。针对脂肪肝疗效,联合治疗组有效率(76.9%)明显高于对照组(20%),治疗组(63.6%)与对照组之间无统计学差异。结论沙格列汀对2型糖尿病合并NAFLD有较好的治疗作用,疗效与二甲双胍相似,其可能通过缓和胰岛素抵抗及降低氧化应激反应来发挥对NAFLD的治疗作用。
OBJECTIVE To observe the clinical efficacy of saxagliptin in the treatment of new diagnosed patients with type 2diabetes and non-alcoholic fatty disease( NAFLD).METHODS Totally 34 patients with type 2 diabetes and NAFLD were divided into3 groups. Patients in the metformin group received metformin 1. 5- 2. 0 g / d,the saxagliptin group received saxagliptin 5 mg / d,or saxagliptin+ metformin group received saxagliptin 5 mg / d and metformin 1.5-2.0 g / d. The changes in following variable were compared before treatment and after treatment. The variables were BMI,fasting glucose,postprandial 2 h glucose,Hb A1 c,blood lipids( TG,TC,LDL-C),liver function( ALT,AST,GGT),HOMA-IR,urine 8-iso-PGF2α. RESULTS After treatment for 6 months,BMI,blood glucose,Hb A1 c,blood lipids,liver function,HOMA-IR and urine 8-iso-PGF2αin saxagliptin group or saxagliptin + metformin group significantly improved compared with pre-treatment. The saxagliptin+metformin group was more effective than metformin group in blood glucose and lipids. As to the fatty liver,the effective rate( 76.9%) in saxagliptin+metformin group was significantly higher than that( 20%) in metformin group, but there was no difference between the saxagliptin group( 63. 6%) and metformin group.CONCLUSION Saxagliptin is effective in the treatment of type 2 diabetes patients complicated with NAFLD by lowering insulin resistance and alleviating oxidative stress,and its effect is similar with metformin.

关键词(KeyWords): 2型糖尿病;非酒精性脂肪肝;沙格列汀
type 2 diabetes;non-alcoholic fatty disease;saxagliptin

Abstract:

Keywords:

基金项目(Foundation): 广东省药学会2型糖尿病用药研究基金(2012C02)

作者(Author): 卢筱华,梁健萍,卢春婷,冯烈
LU Xiaohua,LIANG Jianping,LU Chunting,FENG Lie

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享