今日药学

2021, v.31(09) 708-712

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3例糖尿病足患者引起无症状高尿酸血症分析
Analysis of 3 Cases of Asymptomatic Hyperuricemia caused by Diabetic Foot

罗丽敏;李力任;浦锡娟;
LUO Limin;LI Liren;PU Xijuan;Department of Pharmacy,Guangzhou Development District Hospital;Department of Pharmacy,Nanfang Hospital;

摘要(Abstract):

目的探讨并分析慢性糖尿病足感染引起高尿酸血症的原因及机制。方法通过对3例慢性糖尿病足感染伴高尿酸血症患者,在没有使用降尿酸药物的情况下,感染得到控制后,尿酸快速降为正常水平的案例进行分析。结果慢性糖尿病足感染会通过氧化应激,XO活性上调及产量增加等导致高尿酸血症,但是很有可能是一过性、快速的升高,随着感染控制,尿酸会恢复正常。结论慢性糖尿病足等感染患者有可能引起尿酸的短暂升高,造成高尿酸血症。不建议马上开始降尿酸治疗,应待病情稳定后再作评估,既减少了医疗风险,保证了医疗的安全,也减少药物资源的浪费和患者的经济负担。
OBJECTIVE To explore and analyze the cause and mechanism of hyperuricemia caused by chronic diabetic foot infection. METHODS Three cases of chronic diabetic foot infection with hyperuricemia were analyzed which the uric acid level was quickly dropped to normal without using lowering drugs after the infection was controlled. RESULTS Chronic diabetic foot infection was led to hyperuricemia through peroxidation stress, up-regulation of XO activity and increased uric acid production. But it was likely to be transient and irritable, and the uric acid level would return to normal while the infection was controlled. CONCLUSION Patients with chronic diabetic foot infection may cause temporary increase of uric acid level which will result in hyperuricemia. It is not recommended to start lowering uric acid treatment, and the assessment should be made after the condition is stable. This not only can reduce the medical risk and ensure the safety of medical treatment, but also reduce the waste of medicine resources and the economic burden of patients.

关键词(KeyWords): 糖尿病足;感染;无症状高尿酸血症;尿酸
diabetic foot;infection;asymptomatic hyperuricemia;uric acid

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作者(Author): 罗丽敏;李力任;浦锡娟;
LUO Limin;LI Liren;PU Xijuan;Department of Pharmacy,Guangzhou Development District Hospital;Department of Pharmacy,Nanfang Hospital;

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