余晓霞,吕立,王莹,李国成,刘春霞
YU Xiaoxia,LV Li,WANG Ying,LI Guocheng,LIU Chunxia

• 1:中山大学孙逸仙纪念医院药学部

摘要(Abstract)：

目的研究清咽喉合剂对小鼠耳朵及家兔声带炎症是否具有抑制作用。方法选取小鼠72只,雌雄各半,随机分为模型对照组、清咽喉合剂低剂量组、清咽喉合剂中剂量组、清咽喉合剂高剂量组、蓝芩口服液组、醋酸泼尼松片组,每组12只,采用二甲苯诱导小鼠耳肿胀并检测耳朵肿胀度及肿胀抑制率;选取家兔56只,雌雄各半,随机分为正常对照组、模型对照组、清咽喉合剂低剂量组、清咽喉合剂中剂量组、清咽喉合剂高剂量组、蓝芩口服液组、醋酸地塞米松乳膏组,每组8只,采用巴豆油诱导家兔声带炎症并检测声带指数及声带肿胀抑制率。结果与模型对照组比较,醋酸泼尼松片组和清咽喉合剂高剂量组均对二甲苯诱导的小鼠耳肿胀有明显抑制作用,差异有统计学意义(P<0.05);与模型对照组比较,清咽喉合剂低剂量组,清咽喉合剂中剂量组、清咽喉合剂高剂量组、蓝芩口服液组、醋酸地塞米松乳膏组对巴豆油诱导的家兔声带炎症反应均有明显抑制作用,差异有统计学意义(P<0.05)。结论清咽喉合剂对小鼠耳朵和家兔声带炎症反应具有明显抗炎作用,具体机制尚需进一步研究。
OBJECTIVE To study the anti-inflammatory effects of Qingyanhou Mixture on chorditis vocalis in rabbits and ear inflammation in mouse. METHODS A total of 72 mice in half genders were randomly distributed to model control group,Qingyanhou Mixture low dose group,Qingyanhou Mixture middle dose group,Qingyanhou Mixture high dose group,Lanqin oral solution group and Dexamethasone acetate cream group,each had 12 mice. The mouse ear swelling was induced by xylene,and the mouse ear swelling degree and swelling inhibition rate were detected. 56 rabbits in half genders were randomly divided into normal control group,model control group,Qingyanhou Mixture low dose group,Qingyanhou Mixture middle dose group,Qingyanhou Mixture high dose group,Lanqin oral solution group and Dexamethasone acetate cream group,with 8 rabbits in each group. The rabbits vocal cord inflammation was induced by croton oil,and vocal cord index and vocal cord swelling inhibition rate were detected. RESULTS Compared with the model control group,the Dexamethasone acetate group and Qingyanhou mixture high dose group had significant inhibitory effect on xylene-induced mouse ear swelling,with statistically significant difference( P < 0. 05). Compared with the model control group,the rabbits vesicular inflammation caused by croton oil was significantly inhibited in else groups,the difference was statistically significant( P< 0. 05). CONCLUSION Qingyanhou Mixture has obvious anti-inflammatory effects on chorditis vocalis in rabbits and ear inflammation in mouse,and the mechanism behind the properties needs further study.

关键词(KeyWords)： 清咽喉合剂;小鼠;家兔;抗炎作用
Qingyanhou mixture;mouse;rabbit;anti-inflammatory effect

Abstract:

Keywords:

基金项目(Foundation): 广东省药学会科学研究基金(2014A24);; 建设中医药强省科研课题(20141049)

作者(Author): 余晓霞,吕立,王莹,李国成,刘春霞
YU Xiaoxia,LV Li,WANG Ying,LI Guocheng,LIU Chunxia

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